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Here, we show that important neutrophil responses, such as accumulation of reactive oxygen species and neutrophil extracellular traps, as well as the levels of phagocytosis and killing of the pathogen, differ when comparing diverse\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    isolates. A bloodstream patient isolate previously described as more suited to commensalism than pathogenesis in animal models is relatively \u201csilent\u201d to neutrophils and resistant to killing. Our findings illuminate the relationships between fungal morphogenesis, neutrophil responses, and\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    survival. Our findings suggest that host phenotypes of a commensally adapted strain could be driven by resistance to immune clearance and indicate that we should extend our studies beyond the \u201cprototype\u201d strain SC5314 for deeper understanding of\n                    <jats:italic>Candida<\/jats:italic>\n                    -neutrophil interactions.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00501-20","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T09:45:20Z","timestamp":1597743920000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Natural Variation in Clinical Isolates of Candida albicans Modulates Neutrophil Responses"],"prefix":"10.1128","volume":"5","author":[{"given":"Madhu","family":"Shankar","sequence":"first","affiliation":[{"name":"Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton (Melbourne), Victoria, 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