{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:25:03Z","timestamp":1792607103525,"version":"4.5.0"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["097377"],"award-info":[{"award-number":["097377"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["101873"],"award-info":[{"award-number":["101873"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"RCUK | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/K016393\/1"],"award-info":[{"award-number":["BB\/K016393\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"RCUK | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/P020119\/1"],"award-info":[{"award-number":["BB\/P020119\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>\n                    The rapid global emergence and resistance of\n                    <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n                    <jats:named-content content-type=\"genus-species\">auris<\/jats:named-content>\n                    to current antifungal drugs highlight the importance of understanding the virulence traits exploited by this human fungal pathogen to cause disease. Here, we characterize the stress resistance profile of\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    and the role of the Hog1 stress-activated protein kinase (SAPK) in stress resistance and virulence. Our findings that\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    is acutely sensitive to certain stresses may facilitate control measures to prevent persistent colonization in hospital settings. Furthermore, our observation that the Hog1 SAPK promotes\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    virulence akin to that reported for many other pathogenic fungi indicates that antifungals targeting Hog1 signaling would be broad acting and effective, even on emerging drug-resistant pathogens.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00506-18","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T10:37:58Z","timestamp":1540291078000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":104,"title":["Hog1 Regulates Stress Tolerance and Virulence in the Emerging Fungal Pathogen Candida auris"],"prefix":"10.1128","volume":"3","author":[{"given":"Alison M.","family":"Day","sequence":"first","affiliation":[{"name":"Institute for Cell and Molecular Biosciences, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"McNiff","sequence":"additional","affiliation":[{"name":"Institute for Cell and Molecular Biosciences, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"da Silva Dantas","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-5850","authenticated-orcid":false,"given":"Neil A. R.","family":"Gow","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-7676","authenticated-orcid":false,"given":"Janet","family":"Quinn","sequence":"additional","affiliation":[{"name":"Institute for Cell and Molecular Biosciences, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-17"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0132-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14121"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1863-z"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2016.07.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006290"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz JF Gade L Chow NA Loparev VN Juieng P Farrer RA Litvintseva AP Cuomo CA. 2018. Genomic basis of multidrug-resistance mating and virulence in Candida auris and related emerging species. bioRxiv doi:10.1101\/299917.","DOI":"10.1101\/299917"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00218-17"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00189-16"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12754"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02396-16"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.161320"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01403-18"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.FUNK-0048-2016"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005458"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.10.3058-3068.1999"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-12-13-0355-R"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01913-08"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01872-17"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/205921"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-2009-3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00011-08"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01334-14"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00331-16"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-9-44"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13354"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13264"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-11-0987"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01817-07"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044749"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100390"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-570-1_24"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002074"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-05-0266"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04238.x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.18.2289"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.2.351-361.2003"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500338886"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-03-0181"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12766"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12943"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02229-17"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.5.2.347-358.2006"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005644"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01581-18"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00235-14"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-06-0501"},{"key":"e_1_3_2_53_2","first-page":"198","article-title":"Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs)","volume":"54","author":"Burden N","year":"2015","unstructured":"Burden N, Chapman K, Sewell F, Robinson V. 2015. Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs). J Am Assoc Lab Anim Sci 54:198\u2013208.","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw147"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401648101"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-141-7-1507"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02579"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00340712"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01282-10"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.56"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/34.1.28"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00506-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00506-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:19:19Z","timestamp":1646695159000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00506-18"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,31]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10,31]]}},"alternative-id":["10.1128\/mSphere.00506-18"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00506-18","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,31]]},"assertion":[{"value":"2018-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00506-18"}}