{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:01:41Z","timestamp":1787857301904,"version":"build-2784847793"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100010757","name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","doi-asserted-by":"publisher","award":["NC\/T001240\/1"],"award-info":[{"award-number":["NC\/T001240\/1"]}],"id":[{"id":"10.13039\/501100010757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"UKRI | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L013576\/1"],"award-info":[{"award-number":["BB\/L013576\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204823\/Z\/16\/Z"],"award-info":[{"award-number":["204823\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2023,2,21]]},"abstract":"<jats:p>While we face an acute threat from antibiotic resistant bacteria and a lack of new classes of antibiotic, there are many effective antimicrobials which have limited application due to concerns regarding their toxicity and which could be more useful if such risks are reduced or eliminated. We modified a bolalipid antiseptic used in throat lozenges to see if it could be made more effective against some of the highest-priority bacteria and less toxic.<\/jats:p>","DOI":"10.1128\/msphere.00508-22","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T14:00:20Z","timestamp":1670940020000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Bolaamphiphile Analogues of 12-bis-THA Cl\n            <sub>2<\/sub>\n            Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens"],"prefix":"10.1128","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-6155","authenticated-orcid":false,"given":"Simona","family":"Di Blasio","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-4810","authenticated-orcid":true,"given":"Maria","family":"Clarke","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte K.","family":"Hind","sequence":"additional","affiliation":[{"name":"Technology Development Group, UK Health Security Agency, Research and Evaluation, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Asai","sequence":"additional","affiliation":[{"name":"Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, United Kingdom"},{"name":"MRC Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Laurence","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Benvenuti","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnoor","family":"Hassan","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Semenya","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeDe Kwun-Wai","family":"Man","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"},{"name":"Department of Pharmacology &amp; Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Horrocks","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Manzo","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Van Der Lith","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Lam","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Gentile","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callum","family":"Annette","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-4779","authenticated-orcid":true,"given":"Janine","family":"Bosse","sequence":"additional","affiliation":[{"name":"Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Panaretou","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-4724","authenticated-orcid":true,"given":"Paul R.","family":"Langford","sequence":"additional","affiliation":[{"name":"Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Robertson","sequence":"additional","affiliation":[{"name":"MRC Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny K. W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong"},{"name":"Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Mark","family":"Sutton","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"},{"name":"Technology Development Group, UK Health Security Agency, Research and Evaluation, Salisbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McArthur","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-602X","authenticated-orcid":true,"given":"A. James","family":"Mason","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer &amp; Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"O\u2019Neill J. 2016. Tackling drug-resistant infections globally: final report and recommendations. https:\/\/amr-review.org\/sites\/default\/files\/160518_Final%20paper_with%20cover.pdf. Accessed 18 May 2017."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr030602b"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3914-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600820302"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100404"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1134\/S1990747818020034"},{"key":"e_1_3_2_9_2","first-page":"91","article-title":"DNA binding cationic bolasomes with delocalized charge center. A structure-activity relationship study","volume":"11","author":"Weissig V","year":"2001","unstructured":"Weissig V, Lizano C, Ganellin C, Torchilin V. 2001. DNA binding cationic bolasomes with delocalized charge center. A structure-activity relationship study. STP Pharma Sci 11:91\u201396.","journal-title":"STP Pharma Sci"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.03.031"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50353"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.03.018"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01095-19"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37630-3"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47327-w"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01420-3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2007.03.014"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4236"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.12.010"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/am.17.1.118-127.1969"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv405"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.9.2800-2808.1991"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003981"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.12.015"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11050619"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm2055"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.04.017"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/1995-7645.335703"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.521"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2016.11.005"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/dc9868100303"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0114171"},{"key":"e_1_3_2_33_2","first-page":"27","volume-title":"Perspectives in supramolecular chemistry","author":"Angelova M","year":"2000","unstructured":"Angelova M. 2000. Giant vesicles, p 27\u201336. In Luisi PL, Walde P (ed), Perspectives in supramolecular chemistry. Wiley-Interscience, Chichester, UK."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(79)90079-8"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(71)90351-8"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00572-8"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3670-3676.2004"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00998"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00508-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00508-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T14:41:47Z","timestamp":1676990507000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00508-22"}},"subtitle":[],"editor":[{"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,21]]}},"alternative-id":["10.1128\/msphere.00508-22"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00508-22","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,21]]},"assertion":[{"value":"2022-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00508-22"}}