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Understanding\n                    <jats:italic>T. gondii<\/jats:italic>\n                    \u2019s persistence in neurons holds the potential to identify novel, curative drug targets. The work presented here offers new insights into the neuron-\n                    <jats:italic>T. gondii<\/jats:italic>\n                    interaction\n                    <jats:italic>in vivo<\/jats:italic>\n                    . By transcriptionally profiling neurons manipulated by\n                    <jats:italic>T. gondii<\/jats:italic>\n                    , we unexpectedly revealed that immune cells, and specifically CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, appear to cluster around these neurons, suggesting that CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells specifically recognize parasite-manipulated neurons. Such a possibility supports evidence from other labs that questions the long-standing dogma that neurons are often persistently infected because they are not directly recognized by immune cells such as CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Collectively, these data suggest we reconsider the broader role of neurons in the context of infection and neuroinflammation.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00538-20","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T10:33:07Z","timestamp":1598956387000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Transcriptional Profiling Suggests T Cells Cluster around Neurons Injected with Toxoplasma gondii Proteins"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-4683","authenticated-orcid":false,"given":"Emily F.","family":"Merritt","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate 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