{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:00:41Z","timestamp":1790802041247,"version":"4.1.0"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI124682"],"award-info":[{"award-number":["AI124682"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI116496"],"award-info":[{"award-number":["AI116496"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Toxoplasma gondii<\/jats:named-content>\n                    is a single-celled parasite that persists in its host by converting into a latent cyst stage. This work describes a new transcriptional factor called AP2XII-2 that plays a role in properly maintaining the growth rate of replicating parasites, which contributes to signals required for development into its dormant stage. Without AP2XII-2,\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    parasites experience a delay in their cell cycle that increases the frequency of latent cyst formation. In addition, we found that AP2XII-2 operates in a multisubunit complex with other AP2 factors and chromatin remodeling machinery that represses gene expression. These findings add to our understanding of how\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    parasites balance replication and dormancy, revealing novel points of potential therapeutic intervention to disrupt this clinically relevant process.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00542-20","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T09:01:35Z","timestamp":1600160495000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Toxoplasma gondii AP2XII-2 Contributes to Proper Progression through S-Phase of the Cell Cycle"],"prefix":"10.1128","volume":"5","author":[{"given":"Sandeep","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1823-8642","authenticated-orcid":false,"suffix":"Jr.","given":"William J.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA"},{"name":"Department of Microbiology &amp; Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1767","article-title":"Toxoplasma gondii life cycle in cats","volume":"157","author":"Dubey JP","year":"1970","unstructured":"Dubey JP, Miller NL, Frenkel JK. 1970. 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