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During dissemination in its infected hosts,\n            <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n            breaches endothelial barriers to enter tissues and establish the chronic infections underlying the most severe manifestations of toxoplasmosis. The research presented here examines how\n            <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n            infection of primary human endothelial cells induces changes in cell morphology, barrier function, gene expression, and mechanotransduction signaling under static conditions and under the physiological conditions of shear stress found in the bloodstream. Understanding the molecular interactions occurring at the interface between endothelial cells and\n            <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n            may provide insights into processes linked to parasite dissemination and pathogenesis.\n          <\/jats:p>","DOI":"10.1128\/msphere.00550-19","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T09:40:07Z","timestamp":1580204407000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Toxoplasma gondii Dysregulates Barrier Function and Mechanotransduction Signaling in Human Endothelial Cells"],"prefix":"10.1128","volume":"5","author":[{"given":"Armond L.","family":"Franklin-Murray","sequence":"first","affiliation":[{"name":"Department of Molecular Biology &amp; Biochemistry, University of California, Irvine, California, USA"},{"name":"Institute for Immunology, University 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