{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:10:20Z","timestamp":1791947420340,"version":"4.3.4"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:p>\n            Our study shows a successful prolonged human colonization by a colistin-resistant\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            isolate harboring\n            <jats:italic>mcr-1.2<\/jats:italic>\n            . An intense antibiotic therapy contributed to the maintenance of this microorganism through the acquisition of new resistance genes. The isolates carrying\n            <jats:italic>mcr-1.2<\/jats:italic>\n            showed fewer fitness costs than isogenic isolates with a\n            <jats:italic>pmrB<\/jats:italic>\n            mutation in the chromosome. Coselection and reduced fitness costs may explain the replacement of isolates with the\n            <jats:italic>pmrB<\/jats:italic>\n            mutation by other isolates and the ability of the microorganism to persist despite antibiotic treatment.\n          <\/jats:p>","DOI":"10.1128\/msphere.00551-19","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T14:13:51Z","timestamp":1572963231000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Reduced Fitness Costs of\n            <i>mcr-1.2<\/i>\n            Compared to Mutated\n            <i>pmrB<\/i>\n            in Isogenic Colistin-Resistant KPC-3-Producing Klebsiella pneumoniae"],"prefix":"10.1128","volume":"4","author":[{"given":"Cesira","family":"Giordano","sequence":"first","affiliation":[{"name":"SD Ospedaliera di Microbiologia, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Klak","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Barnini","sequence":"additional","affiliation":[{"name":"SD Ospedaliera di Microbiologia, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika A.","family":"Chlebowicz","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacristina","family":"Menconi","sequence":"additional","affiliation":[{"name":"UO Oncoematologia Pediatrica, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Rossen","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander W.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Bathoorn","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01405-15"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.09.001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00540-X"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.10.011"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00064-16"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00424-7"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky262"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00742-16"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12099"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/165.4.1641"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2319"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw585"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00007-4"},{"key":"e_1_3_1_15_2","first-page":"D81","article-title":"Antimicrobial resistance: is it really all going wrong now?","volume":"160","author":"Bonten M","year":"2016","unstructured":"Bonten M. 2016. 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