{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:11:30Z","timestamp":1790734290467,"version":"4.1.0"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX002711"],"award-info":[{"award-number":["BX002711"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,8,28]]},"abstract":"<jats:p>\n            USA100 health care-associated MRSA isolates are highly antibiotic resistant and can cause invasive disease across all patient populations. Even though USA100 strains are some of the most frequently identified causes of infections, little is known about virulence regulation in these isolates. Our study demonstrates that the USA100\n            <jats:italic>agr<\/jats:italic>\n            quorum-sensing system is important for the control of toxin and exoenzyme production and that the\n            <jats:italic>agr<\/jats:italic>\n            system has a key role in skin infection. In some USA100 isolates, the\n            <jats:italic>agr<\/jats:italic>\n            system is important for growth in the presence of low levels of antibiotics. Altogether, our findings demonstrate that the USA100\n            <jats:italic>agr<\/jats:italic>\n            system is a critical regulator of virulence and that it may make a contribution to the optimal survival of these MRSA strains in the presence of antibiotics.\n          <\/jats:p>","DOI":"10.1128\/msphere.00553-19","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T10:26:18Z","timestamp":1565691978000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Quorum Sensing, Virulence, and Antibiotic Resistance of USA100 Methicillin-Resistant Staphylococcus aureus Isolates"],"prefix":"10.1128","volume":"4","author":[{"given":"Morgan L.","family":"Grundstad","sequence":"first","affiliation":[{"name":"University of Iowa Stead Family Children\u2019s Hospital, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey 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