{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:29:31Z","timestamp":1790386171699,"version":"4.1.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R56AI102503-01A1"],"award-info":[{"award-number":["R56AI102503-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,2,27]]},"abstract":"<jats:p>\n            Methicillin-resistant\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            continues to develop resistance to antimicrobials, including those in current clinical use as daptomycin (DAP). Resistance to DAP arises by mutations in cell membrane and cell wall genes and\/or upregulation of the two-component VraSR system. However, less is known about the connection between the pathogen and virulence traits during DAP resistance development. We provide new insights into VraSR and its regulatory role for virulence factors during DAP resistance, highlighting coordinated interactions that favor the higher persistence of MRSA DAP-resistant strains in the infected host.\n          <\/jats:p>","DOI":"10.1128\/msphere.00557-18","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T11:30:10Z","timestamp":1549971010000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>\n            Infection"],"prefix":"10.1128","volume":"4","author":[{"given":"Agustina","family":"Taglialegna","sequence":"first","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Varela","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto R.","family":"Rosato","sequence":"additional","affiliation":[{"name":"Houston Methodist Cancer Center, Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana E.","family":"Rosato","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2017.11.009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/533591"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir034"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026997"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2581-4"},{"key":"e_1_3_2_8_2","first-page":"391","article-title":"Mechanisms of resistance to daptomycin in Staphylococcus aureus","volume":"30","author":"G\u00f3mez Casanova N","year":"2017","unstructured":"G\u00f3mez Casanova N, Siller Ruiz M, Mu\u00f1oz Bellido JL. 2017. 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