{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:04:11Z","timestamp":1792901051428,"version":"4.5.0"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"EC | Seventh Framework Programme","doi-asserted-by":"publisher","award":["PREPARE (602525)"],"award-info":[{"award-number":["PREPARE (602525)"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>Respiratory syncytial virus (RSV) can cause severe morbidity and mortality in certain risk groups, especially infants and older adults. Currently no (prophylactic) treatment is available, except for a partially effective yet highly expensive monoclonal antibody. RSV therefore remains a major public health concern. To allow targeted development of novel vaccines and therapeutics, it is of great importance to understand the immunological mechanisms that underlie (protection from) severe disease in specific risk populations. Since most RSV-related studies focus on infants, there are only very limited data available concerning the response to RSV in the elderly population. Therefore, in this study, RSV-induced antibody responses and local cytokine secretion were assessed in community-dwelling older adults. These data provide novel insights that will benefit ongoing efforts to design safe and effective prevention and treatment strategies for RSV in an understudied risk group.<\/jats:p>","DOI":"10.1128\/msphere.00577-20","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:33:07Z","timestamp":1598970787000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Antibody and Local Cytokine Response to Respiratory Syncytial Virus Infection in Community-Dwelling Older Adults"],"prefix":"10.1128","volume":"5","author":[{"given":"Xiao","family":"Yu","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-3995","authenticated-orcid":false,"given":"Anke J.","family":"Lakerveld","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Imholz","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie C. A.","family":"ten Brink","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Lie","family":"Mulder","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"de Haan","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger M.","family":"Schepp","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Luytjes","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno D.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josine","family":"van Beek","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-6055","authenticated-orcid":false,"given":"Puck B.","family":"van Kasteren","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy991"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy662"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz059"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/erp.12.45"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00090-16"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/339008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20090"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/421524"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit038"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00580-12"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00548"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4241"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar3534"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2256OC"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4049\/jimmunol.107.1.123","article-title":"Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness","volume":"107","author":"Jt M","year":"1971","unstructured":"Jt M, Van Kirk JE, Wright PF, Chanock RM. 1971. Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness. J Immunol 107:123\u2013130.","journal-title":"J Immunol"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.541-555.2005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030106"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.11.5654-5666.2002"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005318"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00075"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1112"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12861"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/322035"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001038"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822dc8c1"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a14407"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001512"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/515575"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199902000-00007"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.12.010"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01070-15"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110203109"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201304-0750OC"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06757-11"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02119-15"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-014-0041-4"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E10-11-0875"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081695"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-43"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix268"},{"key":"e_1_3_2_42_2","first-page":"321","article-title":"Proefonderzoek naar de frequentie en de aetiologie van griepachtige ziekten in de winter 1963\u20131964","volume":"86","author":"Pel JZS","year":"1965","unstructured":"Pel JZS. 1965. Proefonderzoek naar de frequentie en de aetiologie van griepachtige ziekten in de winter 1963\u20131964. Huisarts Wet 86:321.","journal-title":"Huisarts Wet"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-253"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012465330-6\/50003-8"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00236-19"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-125-7_8"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-9-2215"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00577-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00577-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:36:50Z","timestamp":1696613810000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00577-20"}},"subtitle":[],"editor":[{"given":"Helene F.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10,28]]}},"alternative-id":["10.1128\/mSphere.00577-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00577-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2020-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00577-20"}}