{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:31:18Z","timestamp":1792020678838,"version":"4.4.0"},"reference-count":7,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"DOE | Oak Ridge Institute for Science and Education"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2024,2,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Since 2016, in Colombia, ongoing transmission of\n              <jats:italic>Candida auris<\/jats:italic>\n              has been reported in multiple cities. Here, we provide an updated description of\n              <jats:italic>C. auris<\/jats:italic>\n              genomic epidemiology and the dynamics of antifungal resistance in Colombia. We sequenced 99 isolates from\n              <jats:italic>C. auris<\/jats:italic>\n              cases with collection dates ranging from June 2016 to January 2021; the resulting sequences coupled with 103 previously generated sequences from\n              <jats:italic>C. auris<\/jats:italic>\n              cases were described in a phylogenetic analysis. All\n              <jats:italic>C. auris<\/jats:italic>\n              cases were clade IV. Of the 182 isolates with antifungal susceptibility data, 67 (37%) were resistant to fluconazole, and 39 (21%) were resistant to amphotericin B. Isolates predominately clustered by country except for 16 isolates from Bogot\u00e1, Colombia, which grouped with isolates from Venezuela. The largest cluster (\n              <jats:italic>N<\/jats:italic>\n              = 166 isolates) contained two subgroups. The first subgroup contained 26 isolates, mainly from C\u00e9sar; of these, 85% (\n              <jats:italic>N<\/jats:italic>\n              = 22) were resistant to fluconazole. The second subgroup consisted of 47 isolates from the north coast; of these, 81% (\n              <jats:italic>N<\/jats:italic>\n              = 38) were resistant to amphotericin B. Mutations in the\n              <jats:italic>ERG11<\/jats:italic>\n              and\n              <jats:italic>TAC1B<\/jats:italic>\n              genes were identified in fluconazole-resistant isolates. This work describes molecular mechanisms associated with\n              <jats:italic>C. auris<\/jats:italic>\n              antifungal resistance in Colombia. Overall,\n              <jats:italic>C. auris<\/jats:italic>\n              cases from different geographic locations in Colombia exhibited high genetic relatedness, suggesting continued transmission between cities since 2016. These findings also suggest a lack of or minimal introductions of different clades of\n              <jats:italic>C. auris<\/jats:italic>\n              into Colombia.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              <jats:italic>Candida auris<\/jats:italic>\n              is an emerging fungus that presents a serious global health threat and has caused multiple outbreaks in Colombia. This work discusses the likelihood of introductions and local transmission of\n              <jats:italic>C. auris<\/jats:italic>\n              and provides an updated description of the molecular mechanisms associated with antifungal resistance in Colombia. Efforts like this provide information about the evolving\n              <jats:italic>C. auris<\/jats:italic>\n              burden that could help guide public health strategies to control\n              <jats:italic>C. auris<\/jats:italic>\n              spread.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/msphere.00577-23","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T14:01:53Z","timestamp":1706796113000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Genomic epidemiology and antifungal-resistant characterization of\n            <i>Candida auris<\/i>\n            , Colombia, 2016\u20132021"],"prefix":"10.1128","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6243-7716","authenticated-orcid":true,"given":"Elizabeth","family":"Misas","sequence":"first","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L.","family":"Escand\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Gade","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-9809","authenticated-orcid":true,"given":"Diego H.","family":"Caceres","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"},{"name":"Center of Expertise in Mycology Radboudumc\/CWZ, Nijmegen, the Netherlands"},{"name":"Studies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School ofMedicine and Health Sciences, Universidad del Rosario, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Hurst","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc","family":"Le","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Min","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Lyman","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Duarte","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Chow","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/2023.08.01.23293435"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy411"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13390"},{"key":"e_1_3_4_6_2","volume-title":"Grupo de Microbiologia","author":"Escand\u00f3n P","year":"2016","unstructured":"Escand\u00f3n P, Editor. 2016. Alerta Por emergencia global de infecciones invasivas causadas por la levadura multirresistente, Candida auris, I.N.d.S. In Grupo de Microbiologia"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03364-19"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02663-20"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00577-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00577-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T18:44:15Z","timestamp":1723401855000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00577-23"}},"subtitle":[],"editor":[{"given":"Rebecca S.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,28]]}},"alternative-id":["10.1128\/msphere.00577-23"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00577-23","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]},"assertion":[{"value":"2023-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00577-23"}}