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Treatment of shigellosis includes oral fluids and antibiotics, but the high burden of disease, increasing prevalence of antibiotic resistance, and long-term health consequences clearly warrant the development of an effective vaccine. One\n            <jats:italic>Shigella<\/jats:italic>\n            vaccine under development is termed the invasin complex or Invaplex and is designed to drive an immune response to specific antigens of the bacteria in an effort to protect an individual from infection. The work presented here describes the production and evaluation of a new generation of Invaplex. The improved vaccine stimulates the production of antibodies in immunized mice and guinea pigs and protects these animals from\n            <jats:italic>Shigella<\/jats:italic>\n            infection. The next step in the product\u2019s development will be to test the safety and immune response induced in humans immunized with Invaplex.\n          <\/jats:p>","DOI":"10.1128\/msphere.00583-17","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T10:07:43Z","timestamp":1522145263000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Assembly, Biochemical Characterization, Immunogenicity, Adjuvanticity, and Efficacy of\n            <i>Shigella<\/i>\n            Artificial Invaplex"],"prefix":"10.1128","volume":"3","author":[{"given":"K. 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