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The disease causes severe economic losses in terms of production due to high mortality and morbidity in nonvaccinated chickens. Despite extensive vaccination approaches, Newcastle disease (ND) remains a permanent threat to the poultry industry worldwide. In the current study, we used natural chicken IFN-\u03b1 as an innate immune modulator to counteract ND in chickens. We report that chIFN-\u03b1 is effective in protecting the chickens against ND and also prevents shedding of the virus, which can then prevent further spread of the disease. We propose that in addition to vaccination, chIFN-\u03b1 therapy could be an effective option for controlling ND in areas of endemicity.<\/jats:p>","DOI":"10.1128\/msphere.00585-20","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T14:30:02Z","timestamp":1594737002000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Comparative Study of Protection against Newcastle Disease in Young Broilers Administered Natural Chicken Alpha Interferon via Oral and Intramuscular Routes"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8761-8369","authenticated-orcid":false,"given":"Faisal Rasheed","family":"Anjum","sequence":"first","affiliation":[{"name":"Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Aamir","family":"Aslam","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas Sarwar","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-019-01843-z"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7278459"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.12.019"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(99)00069-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0590240"},{"key":"e_1_3_2_7_2","unstructured":"Razmaraii N Toroghi N Babaei H Khalili I Sadigh ES Froghy L. 2012. 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