{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:01:59Z","timestamp":1778144519655,"version":"3.51.4"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2017YFD0500102"],"award-info":[{"award-number":["2017YFD0500102"]}]},{"name":"National Key Research and Development Program of China","award":["2016YFD0501304"],"award-info":[{"award-number":["2016YFD0501304"]}]},{"name":"German Federal Ministry of Education and Research","award":["01KI1727D"],"award-info":[{"award-number":["01KI1727D"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,10,30]]},"abstract":"<jats:p>\n            The global dissemination of carbapenem resistance genes is of great concern. Animals are usually considered a reservoir of resistance genes and an important source of human infection. Although carbapenemase-producing\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            strains of animal origin have been reported increasingly,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>KPC-2<\/jats:sub>\n            -positive strains from food-producing animals are still rare. In this study, we first describe the isolation and characterization of a carbapenem-resistant\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            ST11 isolate, strain K15, which is of pig origin and coproduces KPC-2 and FosA3 via two novel hybrid plasmids. Furthermore, our findings highlight that this ST11\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            strain K15 is most likely of human origin and could be easily transmitted back to humans via direct contact or food intake. In light of our findings, significant attention must be paid to monitoring the prevalence and further evolution of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>KPC-2<\/jats:sub>\n            -carrying plasmids among the\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            strains of animal origin.\n          <\/jats:p>","DOI":"10.1128\/msphere.00590-19","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T13:22:36Z","timestamp":1568121756000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Characterization of a Multidrug-Resistant Porcine Klebsiella pneumoniae Sequence Type 11 Strain Coharboring\n            <i>bla<\/i>\n            <sub>KPC-2<\/sub>\n            and\n            <i>fosA3<\/i>\n            on Two Novel Hybrid 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