{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:24:26Z","timestamp":1774049066659,"version":"3.50.1"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2025,2,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Miguel Chiurillo works in the field of protein kinases, studying their role in cell signaling and cell cycle progression in\n              <jats:italic>Trypanosoma cruzi<\/jats:italic>\n              . In this mSphere of Influence article, he reflects on how the research articles \u201cSystematic functional analysis of\n              <jats:italic>Leishmania<\/jats:italic>\n              protein kinases identifies regulators of differentiation or survival\u201d by Baker et al. and \u201cScreening the\n              <jats:italic>Toxoplasma<\/jats:italic>\n              kinome with high throughput tagging identifies a regulator of invasion and egress\u201d by Smith et al. made an impact on his understanding of the complexity of the\n              <jats:italic>Trypanosoma cruzi<\/jats:italic>\n              kinome and the challenges to unravel it.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/msphere.00598-24","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T14:00:26Z","timestamp":1738072826000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["mSphere of Influence: The challenge of screening for essential protein kinases in\n            <i>Trypanosoma cruzi<\/i>"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-9027","authenticated-orcid":true,"given":"Miguel A.","family":"Chiurillo","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Cincinnati","place":["Cincinnati, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2022.08.009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-6-127"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075762"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0356-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0745-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr500197d"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.15698\/mic2021.09.758"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007828"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21360-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01104-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jeu.12999"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00738-21"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104857"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00598-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00598-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:03:50Z","timestamp":1740492230000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00598-24"}},"subtitle":[],"editor":[{"given":"Silvia N. J.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,25]]}},"alternative-id":["10.1128\/msphere.00598-24"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00598-24","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]},"assertion":[{"value":"2025-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00598-24"}}