{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:07:05Z","timestamp":1790500025455,"version":"4.1.0"},"reference-count":66,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI124499"],"award-info":[{"award-number":["R01AI124499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001774","name":"New Jersey Health Foundation","doi-asserted-by":"publisher","award":["PC 40-18"],"award-info":[{"award-number":["PC 40-18"]}],"id":[{"id":"10.13039\/100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,8,26]]},"abstract":"<jats:p>\n                    The emergence of resistance in\n                    <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n                    , an opportunistic pathogen, against the commonly used antifungals is becoming a major obstacle in its treatment. The necessity to identify new drug targets demands fundamental insights into the mechanisms used by this organism to develop drug resistance.\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    has introns in 4 to 6% of its genes, the functions of which remain largely unknown. Using the RNA-sequencing data from isogenic pairs of azole-sensitive and -resistant isolates of\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    , here, we show how\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    uses modulations in mRNA splicing to overcome antifungal drug stress.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00608-20","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T08:37:19Z","timestamp":1597221439000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Identification of Genomewide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of Candida albicans Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses"],"prefix":"10.1128","volume":"5","author":[{"given":"Suraya","family":"Muzafar","sequence":"first","affiliation":[{"name":"Amity Institute of Integrative Sciences and Health, Amity University Gurgaon, Gurgaon, India"},{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Datta","family":"Sharma","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Sciences and Health, Amity University Gurgaon, Gurgaon, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Haseeb","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Bioresources, University of Kashmir, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem A.","family":"Gaur","sequence":"additional","affiliation":[{"name":"Yeast Biofuel Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujjaini","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Sciences and Health, Amity University Gurgaon, Gurgaon, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-9897","authenticated-orcid":false,"given":"Neeraj","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Prasad","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Sciences and Health, Amity University Gurgaon, Gurgaon, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283536ba8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy776"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019752"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20160067"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00103-08"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-030117-020345"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41513-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.FUNK-0048-2016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08909"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.07.083"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034316"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.012809.104729"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2164"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003376"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32252"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004261"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760170519"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvi.2011.05.015"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature724"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.109.105155"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dss007"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2011.00761.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003160"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.07.018"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050090"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6111907"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02313"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1357"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401648101"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.109553.110"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1482"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.1999.00498.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00280-11"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06528.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1138201"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0074-02762012000800006"},{"key":"e_1_3_2_39_2","first-page":"1051","article-title":"Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model","volume":"6","author":"Chaves GM","year":"2007","unstructured":"Chaves GM, Bates S, Maccallum DM, Odds FC. 2007. Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model. Genet Mol Res 6:1051\u20131063.","journal-title":"Genet Mol Res"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-03-0179"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108095200"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513447112"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-11-3705"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-4165(99)00020-3"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.12.021"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.1.76"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03570-14"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.021"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7050131"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330433"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2294-y"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.084"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019101597"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.201400903"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05788-11"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-00088-y"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0859-7"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.008"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1203"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00864-12"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00328721"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.2.298-309.2005"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140487"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.8.1328-1342.2005"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045109"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00046-8"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00608-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00608-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T14:47:24Z","timestamp":1723387644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00608-20"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,26]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8,26]]}},"alternative-id":["10.1128\/msphere.00608-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00608-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,26]]},"assertion":[{"value":"2020-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"10.1128\/msphere.00608-20"}}