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This organism frequently acquires resistance to antifungal agents through rapid generation of genetic diversity, with aneuploidy serving as a particularly important adaptive mechanism. This paper describes an investigation of the sole kinesin-5 in\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            , which is a major regulator of chromosome segregation. Contrary to other eukaryotes studied thus far,\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            does not require kinesin-5 function for bipolar spindle assembly or spindle elongation. Rather, this motor protein associates with the spindle throughout mitosis to maintain spindle integrity. Furthermore, kinesin-5 loss is synthetically lethal with loss of kinesin-14\u2014canonically an opposing force producer to kinesin-5 in spindle assembly and anaphase. These results suggest a significant evolutionary rewiring of microtubule motor functions in the\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            mitotic spindle, which may have implications in the genetic instability of this pathogen.\n          <\/jats:p>","DOI":"10.1128\/msphere.00610-19","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T11:05:58Z","timestamp":1573556758000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Kinesin-5 Is Dispensable for Bipolar Spindle Formation and Elongation in Candida albicans, but Simultaneous Loss of Kinesin-14 Activity Is Lethal"],"prefix":"10.1128","volume":"4","author":[{"given":"Irsa","family":"Shoukat","sequence":"first","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, 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