{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:56:17Z","timestamp":1760648177730,"version":"3.41.2"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2025,3,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Luisa Bern\u00e1 works in the field of comparative and evolutionary genomics in unicellular eukaryotes. In this mSphere of Influence article, she reflects on how advances in three-dimensional genome organization have reshaped our understanding of parasite biology. She discusses how recent findings uncover the distinctiveness of the three-dimensional architecture of\n              <jats:italic>Trypanosoma cruzi\u2019<\/jats:italic>\n              s genome and its functional implications. Bern\u00e1 argues that integrating structural genomics into parasite research is essential for advancing our understanding of genome organization and its role in shaping parasite biology, particularly in the context of neglected tropical diseases.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/msphere.00611-24","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T14:00:38Z","timestamp":1740578438000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["mSphere of Influence:\n            <i>Trypanosoma cruzi<\/i>\n            genome in 3D action"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-3414","authenticated-orcid":true,"given":"Luisa","family":"Bern\u00e1","sequence":"first","affiliation":[{"name":"Laboratorio de Interacciones Hospedero-Pat\u00f3geno-UBM, Institut Pasteur de Montevideo","place":["Montevideo, Uruguay"]},{"name":"Laboratorio de Apicomplejos, Institut Pasteur de Montevideo","place":["Montevideo, Uruguay"]},{"name":"Unidad de Bioinform\u00e1tica, Institut Pasteur de Montevideo","place":["Montevideo, Uruguay"]},{"name":"Laboratorio de Gen\u00f3mica Evolutiva, Facultad de Ciencias, Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.26.1.281"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003889"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00388453"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00388452"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000177"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52449-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009254"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-022-00450-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-6851(00)00349-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01483-y"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00611-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00611-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T15:24:02Z","timestamp":1742916242000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00611-24"}},"subtitle":[],"editor":[{"given":"Maria E.","family":"Francia","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,25]]}},"alternative-id":["10.1128\/msphere.00611-24"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00611-24","relation":{},"ISSN":["2379-5042"],"issn-type":[{"type":"electronic","value":"2379-5042"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00611-24"}}