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For example, defining the early evolutionary patterns of humoral immunity to SARS-CoV-2, and whether prevalent coronaviruses or other common infections influence the evolution of immunity, remains poorly understood but could inform diagnostic and vaccine development. Here, we deeply profiled the evolution of SARS-CoV-2 immunity, and how it is influenced by other coinfections. Our data suggest an early and rapid rise in functional humoral immunity in the first 2 weeks of infection across antigen-specific targets, which is negligibly influenced by cross-reactivity to additional common coronaviruses or common respiratory infections. These data suggest that preexisting receptor binding domain-specific immunity does not influence or bias the evolution of immunity to SARS-CoV-2 and should have negligible influence on shaping diagnostic or vaccine-induced immunity.<\/jats:p>","DOI":"10.1128\/msphere.00622-20","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:33:07Z","timestamp":1598970787000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Evolution of Early SARS-CoV-2 and Cross-Coronavirus Immunity"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-0627","authenticated-orcid":false,"given":"Carolin","family":"Loos","sequence":"first","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Atyeo","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"},{"name":"Harvard Virology Program, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Fischinger","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"},{"name":"Virology and Immunology Program, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Burke","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Slein","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Streeck","sequence":"additional","affiliation":[{"name":"Department of Virology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Lauffenburger","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Harvard T.H. 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