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Yeasts that cause significant human disease were quickly incorporated into these investigations to define the genetic and phenotypic drivers of virulence. Among\n              <jats:italic>Candida<\/jats:italic>\n              species,\n              <jats:italic>Candida albicans<\/jats:italic>\n              has emerged as a model for studying genomic processes of evolution because of its clinical relevance, relatively small genome, and ability to tolerate complex chromosomal changes. Here, we describe major recent findings that used evolution of strains from defined genetic backgrounds to delineate mutational and adaptative processes and include how nascent exploration into naturally occurring variation is contributing to these conceptual frameworks. Ultimately, efforts to discern adaptive mechanisms used by\n              <jats:italic>C. albicans<\/jats:italic>\n              will continue to divulge new biology and can better inform treatment regimens for the increasing prevalence of fungal disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/msphere.00641-23","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T13:02:34Z","timestamp":1721134954000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Evolution and strain diversity advance exploration of\n            <i>Candida albicans<\/i>\n            biology"],"prefix":"10.1128","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-2170","authenticated-orcid":false,"given":"Matthew Z.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Laboratory of Genetics, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Center for Genomic Science Innovation, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4028-3725","authenticated-orcid":false,"given":"Siobhan M.","family":"Dietz","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Pathology Graduate Program, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.05.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806002115"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2218163120"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0537"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.03.019"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.02.008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-4-r52"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08064"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.097501.109"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.174623.114"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00129-11"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.178020"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00662"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00578-19"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008137"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.009"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04787-4"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01205-18"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5431.1271"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00209-09"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031631"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11111289"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.01.022"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2016.08.011"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01146-18"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2018.09.001"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00087-23"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11081870"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","unstructured":"Acosta-Zald\u00edvar M Qi W Mishra A Roy U King WR Patton-Vogt J Anderson MZ K\u00f6hler JR. 2024. 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