{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:13:25Z","timestamp":1769922805920,"version":"3.49.0"},"reference-count":121,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2025,1,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Heat shock factor (HSF)-type regulators are stress-responsive transcription factors widely distributed among eukaryotes, including fungi. They carry a four-stranded winged helix-turn-helix DNA-binding domain considered as the signature domain for HSFs. The genome of the opportunistic yeast\n              <jats:italic>Candida albicans<\/jats:italic>\n              encodes four HSF members, namely, Sfl1, Sfl2, Skn7, and the essential regulator, Hsf1.\n              <jats:italic>C. albicans<\/jats:italic>\n              HSFs do not only respond to heat shock and\/or temperature variation but also to CO\n              <jats:sub>2<\/jats:sub>\n              levels, oxidative stress, and quorum sensing, acting this way as central decision makers. In this minireview, I follow on the heels of my mSphere of Influence commentary (2020) to provide an overview of the repertoire of HSF regulators in\n              <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n              and\n              <jats:italic>C. albicans<\/jats:italic>\n              and describe how their genetic perturbation in\n              <jats:italic>C. albicans<\/jats:italic>\n              , coupled with genome-wide expression and location analyses, allow to map their transcriptional circuitry. I highlight how they can regulate, in common, a crucial developmental program: filamentous growth.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/msphere.00644-23","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T14:00:12Z","timestamp":1734703212000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["When HSFs bring the heat\u2014mapping the transcriptional circuitries of HSF-type regulators in\n            <i>Candida albicans<\/i>"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-2218","authenticated-orcid":true,"given":"Sadri","family":"Znaidi","sequence":"first","affiliation":[{"name":"Institut Pasteur de Tunis, University of Tunis El Manar, Laboratoire de Microbiologie Mol\u00e9culaire, Vaccinologie et D\u00e9veloppement Biotechnologique","place":["Tunis, Tunisia"]},{"name":"Institut Pasteur, INRA, D\u00e9partement Mycologie, Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques","place":["Paris, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00576.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad684"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.12.4241"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200303030"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23425-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.22850"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(88)91219-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E23-05-0153"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14821"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.07.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00516-23"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2024.102493"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2154548"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00043-22"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.605711"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20010-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.157"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003780"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001510"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.11.008"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2005.01.012"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.12.013"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-08-0499"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06301.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-08-0546"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.15698\/mic2019.11.697"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.3.5.1111-1123.2004"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-09-0946"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.088930"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.4.12364"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-40204-4_3"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.8.11.5040-5042.1988"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411256200"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10317"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.05.014"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.008822"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31668"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2004.12.008"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560031020"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/8269"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.11.110195.002301"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa913"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku949"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06849.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.21.6908-6915.1993"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004380050824"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02208613"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.5.1035"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.7.2335"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111547200"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4742"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-007-0136-z"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(89)90424-1"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.19.5757"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124396"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004570"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.12.3981-3993.2002"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13783"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.117.042440"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/150.4.1443"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1389306"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa937"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18546.1"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2018_144"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17625"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00917-19"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.07.005"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst042"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06883.x"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032467"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2010.08.010"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003069"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11704"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02800"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007270"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00236-07"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00199-07"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05060-11"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8010075"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2022.2046952"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007316"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2023.01.011"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2020.151414"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003519"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2010.00710.x"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00291-09"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006949"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00311211"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-017-0797-1"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00245-10"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.6.1304-1314.2003"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-09-0434"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.23.6952"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.23.16040"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04917.x"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00021-09"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00328-10"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13758"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045912"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2390-2394.2004"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.1158"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.04.014"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.050682"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad849"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1104"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002190"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.113.153262"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0360758"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-215"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1325605"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605140103"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.960884"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00002-09"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12890"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00070-08"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.6.548"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2024.168642"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0760-7"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-05892-5"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011833"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.042"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00644-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00644-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T14:01:52Z","timestamp":1738072912000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00644-23"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":121,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,28]]}},"alternative-id":["10.1128\/msphere.00644-23"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00644-23","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"assertion":[{"value":"2024-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00644-23"}}