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A modern CHIM of GAS pharyngitis could help to accelerate vaccine development and drive pathogenesis research. Challenge strain selection is critical to the safety and success of any CHIM and especially so for an organism such as GAS, with its wide strain diversity and potential to cause severe life-threatening acute infections (e.g., toxic shock syndrome and necrotizing fasciitis) and postinfectious complications (e.g., acute rheumatic fever, rheumatic heart disease, and acute poststreptococcal glomerulonephritis). In this paper, we outline the rationale for selecting an\n                    <jats:italic>emm<\/jats:italic>\n                    75 strain for initial use in a GAS pharyngitis CHIM in healthy adult volunteers, drawing on the findings of a broad characterization effort spanning molecular epidemiology,\n                    <jats:italic>in vitro<\/jats:italic>\n                    assays, whole-genome sequencing, and animal model studies.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00647-18","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T06:30:10Z","timestamp":1549953010000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["A Controlled Human Infection Model of Group A\n                    <i>Streptococcus<\/i>\n                    Pharyngitis: Which Strain and Why?"],"prefix":"10.1128","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-6700","authenticated-orcid":false,"given":"Joshua","family":"Osowicki","sequence":"first","affiliation":[{"name":"Tropical Diseases, Murdoch Children\u2019s Research Institute, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Infectious Diseases Unit, Department of General Medicine, The Royal Children\u2019s Hospital Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy I.","family":"Azzopardi","sequence":"additional","affiliation":[{"name":"Tropical Diseases, Murdoch Children\u2019s Research Institute, Melbourne, Victoria, 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Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara","family":"Baker","sequence":"additional","affiliation":[{"name":"Tropical Diseases, Murdoch Children\u2019s Research Institute, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-3055","authenticated-orcid":false,"given":"Christine M.","family":"Gillen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Walker","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, 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