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No licensed vaccine exists to prevent<jats:italic>C. trachomatis<\/jats:italic>infection, and investigations of the natural immune response may inform the design of targeted vaccines for<jats:italic>C. trachomatis<\/jats:italic>. Our study fills a gap in knowledge regarding the epitope specificity of antibody responses that are elicited in response to<jats:italic>C. trachomatis<\/jats:italic>infection in women. We identified several new B cell epitopes for<jats:italic>C. trachomatis<\/jats:italic>antigens and confirmed B cell epitopes that have been identified by other methods. Our finding that women produce antibodies to the VD4-MOMP regardless of infection outcome provides insight into vaccine development, suggesting that vaccines targeting VD4-MOMP may need to elicit higher-titer antibody responses than natural infection imparts or that additional vaccine targets should be pursued in the future.<\/jats:p>","DOI":"10.1128\/msphere.00654-20","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T13:55:19Z","timestamp":1600782919000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Antibodies to Variable Domain 4 Linear Epitopes of the<i>Chlamydia trachomatis<\/i>Major Outer Membrane Protein Are Not Associated with Chlamydia Resolution or Reinfection in Women"],"prefix":"10.1128","volume":"5","author":[{"given":"Amanda L.","family":"Collar","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandria C.","family":"Linville","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan B.","family":"Core","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosette M.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Peabody","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce","family":"Chackerian","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1428-8899","authenticated-orcid":false,"given":"Kathryn M.","family":"Frietze","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"},{"name":"Clinical and Translational Science Center, University of New Mexico Health Sciences, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Sexually transmitted disease surveillance, 2018","author":"CDC","year":"2018","unstructured":"CDC. 2018. 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