{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:30:28Z","timestamp":1780615828942,"version":"3.54.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100018022","name":"San Antonio Life Sciences Institute","doi-asserted-by":"crossref","award":["Innovation Challenge Award"],"award-info":[{"award-number":["Innovation Challenge Award"]}],"id":[{"id":"10.13039\/100018022","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Margaret Batts Tobin Foundation"},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI127692"],"award-info":[{"award-number":["R01AI127692"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI130668"],"award-info":[{"award-number":["R21AI130668"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI129883"],"award-info":[{"award-number":["R21AI129883"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI142560"],"award-info":[{"award-number":["R21AI142560"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI117299"],"award-info":[{"award-number":["R21AI117299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,10,30]]},"abstract":"<jats:p>\n            Many immunocompromised individuals, including HIV\/AIDS and cancer patients, are susceptible to candidiasis. About half of all cases are caused by the major fungal pathogen\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            , whereas the remainder are due to less pathogenic non-\n            <jats:italic>albicans Candida<\/jats:italic>\n            species (NACS). Generation of filamentous cells represents a major virulence property of\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            , and the NACS are believed to be less pathogenic, in part, because they do not filament as well as\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            does. To address this question, we determined the pathogenicity of two NACS strains that have been genetically engineered to promote filamentation during infection. Surprisingly, these strains showed a dramatic reduction in pathogenicity. The host immune response did not appear to be affected. However, unlike\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            , filamentation of the NACS was associated with downregulation of several genes important for pathogenicity processes. Our results suggest that there are fundamental evolutionary differences in the relationship between filamentation and pathogenesis in NACS compared to\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/msphere.00656-19","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T11:18:16Z","timestamp":1571138296000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Filamentation Is Associated with Reduced Pathogenicity of Multiple Non-\n            <i>albicans Candida<\/i>\n            Species"],"prefix":"10.1128","volume":"4","author":[{"given":"Mohua","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Lazzell","sequence":"additional","affiliation":[{"name":"Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus A.","family":"Romo","sequence":"additional","affiliation":[{"name":"Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Lopez-Ribot","sequence":"additional","affiliation":[{"name":"Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7237-8481","authenticated-orcid":false,"given":"David","family":"Kadosh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Candida and candidosis","author":"Odds FC","year":"1988","unstructured":"Odds FC. 1988. Candida and candidosis, 2nd ed. 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Emergence of non-Candida albicans Candida species as pathogens, p 37\u201354. In Calderone RA (ed), Candida and candidiasis. 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