{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:08:01Z","timestamp":1791832081739,"version":"4.3.4"},"reference-count":105,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Commonwealth Universal Research Enhancement","award":["SAP # 4100068710"],"award-info":[{"award-number":["SAP # 4100068710"]}]},{"name":"NIH\/Boehringer Ingelheim Summer Program"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,8,26]]},"abstract":"<jats:p>\n                    While enteric parasitic infections are among the most important infections in lower- and middle-income countries, their impact on gut microbiota is poorly understood. We reasoned that clinical symptoms associated with these infections may be influenced by alterations of the microbiome that occur during infection. To explore this notion, we took a two-pronged approach. First, we studied a cohort of dogs naturally infected with various enteric parasites and found a strong association between parasite infection and altered gut microbiota composition.\n                    <jats:italic>Giardia<\/jats:italic>\n                    , one of the most prevalent parasite infections globally, had a particularly large impact on the microbiome. Second, we took a database-driven strategy to integrate microbiome data with clinical data from large human field studies and found that\n                    <jats:italic>Giardia<\/jats:italic>\n                    infection is also associated with marked alteration of the gut microbiome of children, suggesting a possible explanation for why\n                    <jats:italic>Giardia<\/jats:italic>\n                    has been reported to be associated with protection from moderate to severe diarrhea.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00670-20","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T09:40:42Z","timestamp":1596534042000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Natural Infection with\n                    <i>Giardia<\/i>\n                    Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-5521","authenticated-orcid":false,"given":"Alexander S. F.","family":"Berry","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"},{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylynn","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan C.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Farias Amorim","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Putre","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiysha","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Baldassano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2865-4589","authenticated-orcid":false,"given":"Daniel P.","family":"Beiting","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"387","article-title":"Human intestinal parasites","volume":"25","author":"Haque R","year":"2007","unstructured":"Haque R. 2007. Human intestinal parasites. J Health Popul Nutr 25:387\u2013391.","journal-title":"J Health Popul Nutr"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268819000165"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05038-11"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis761"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-012-3085-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmw111"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00037-17"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02089.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","unstructured":"Reh L Muadica AS K\u00f6ster PC Balasegaram S Verlander NQ Ch\u00e9rcoles ER Carmena D. 2019. Substantial prevalence of enteroparasites Cryptosporidium spp. Giardia duodenalis and Blastocystis sp. in asymptomatic schoolchildren in Madrid Spain November 2017 to June 2018. Euro Surveill 24(43):1900241. doi:10.2807\/1560-7917.ES.2019.24.43.1900241.","DOI":"10.2807\/1560-7917.ES.2019.24.43.1900241"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00935-19"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.06.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00948-16"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00335.2014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.21307\/jofnem-2017-082"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006471"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199754050-00003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30412-x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0416-5"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2019.104010"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.07.041"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.07.044"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0740-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i9.1050"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2741\/470"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200685"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.177"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051907"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00067-06"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0450-3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30351-6"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13559"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-6-r76"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu653"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz906"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1105"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.3522209"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz905"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.009"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317855"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2019.01.002"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125495"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125945"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159770"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008066"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6200"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076573"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-2739-2"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-JAALAS-19-000113"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228145"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis762"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(02)01607-6"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70808-4"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004283"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00151-5"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000293"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.08.007"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.11.029"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmt085"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001158"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.11.005"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2019.12.011"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04073-7"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00007-18"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007295"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1187703"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1086\/315409"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90531-T"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(79)80011-6"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01535792"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.11.010"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0495-4"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001049"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.04.006"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1086\/498169"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2003.00634.x"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(01)00183-7"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5811.449"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw391"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14832"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010667"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2505"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00114"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0404-3"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01043-13"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf436"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009490"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01996-06"},{"key":"e_1_3_2_92_2","unstructured":"Sorensen T. 1948. A method of establishing groups of equal amplitude in plant sociology based on similarity of species content and its application to analyses of vegetation on Danish Commons. Kongelige Danske Videnskabernes Selskab Biologiske Skrifter Bind 5 Nr. 4."},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0470-z"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.139"},{"key":"e_1_3_2_96_2","unstructured":"Oksanen J Blanchet FG Friendly M Kindt R Legendre P McGlinn D Minchin PR O\u2019Hara RB Simpson GL Solymos P Stevens MHH Szoecs E Wagner H. 2019. vegan: community ecology package. Computer software R."},{"key":"e_1_3_2_97_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2018","unstructured":"R Core Team. 2018. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_3_2_99_2","volume-title":"ggplot2 \u2212 elegant graphics for data analysis","author":"Wickham H","year":"2016","unstructured":"Wickham H. 2016. ggplot2 \u2212 elegant graphics for data analysis. Springer-Verlag, New York, NY."},{"key":"e_1_3_2_100_2","unstructured":"Pedersen TL. 2017. patchwork: the composer of ggplots. Computer software R."},{"key":"e_1_3_2_101_2","unstructured":"Arnold JB. 2019. ggthemes: extra themes scales and geoms for \u201cggplot2.\u201d Computer software R."},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1890\/08-1823.1"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1027"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1209"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1616-9"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00670-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00670-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T14:46:41Z","timestamp":1723387601000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00670-20"}},"subtitle":[],"editor":[{"given":"June","family":"Round","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,26]]},"references-count":105,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8,26]]}},"alternative-id":["10.1128\/msphere.00670-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00670-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,26]]},"assertion":[{"value":"2020-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"10.1128\/msphere.00670-20"}}