{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:27:34Z","timestamp":1791844054502,"version":"4.3.4"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Universita degli studi di Milano-Linea B"},{"name":"BBSRC Industrial CASE","award":["BB\/P504567\/1"],"award-info":[{"award-number":["BB\/P504567\/1"]}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["097377\/Z\/11\/Z"],"award-info":[{"award-number":["097377\/Z\/11\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,2,27]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n                    is the most common human fungal pathogen with an estimated crude mortality rate of 40%. The ability of the organism to switch from the yeast to hyphal form and produce biofilms are important virulence factors.\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    infections are combatted by the host immune system. However,\n                    <jats:italic>Candida<\/jats:italic>\n                    triggers a strong inflammatory response that, if not appropriately regulated, can damage host tissues. Therefore, it is important that the host immune response eliminates the fungus but limits tissue damage. This study provides evidence that targeting cholinergic receptors cannot only curb the virulence of\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    by inhibiting filamentous growth and biofilm formation but can also appropriately regulate the host immune response to induce rapid clearance with limited damage to vital tissues. This article provides evidence that repurposing licensed drugs that target cholinergic receptors may offer novel therapeutic solutions for the prevention or treatment of fungal infections.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00689-18","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T09:45:41Z","timestamp":1548236741000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections"],"prefix":"10.1128","volume":"4","author":[{"given":"Christopher","family":"Nile","sequence":"first","affiliation":[{"name":"Oral Sciences Research Group, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United 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