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Antifungal therapies are limited in efficiency and availability. In this research, we describe the regulation of riboflavin production in\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            . Since riboflavin biosynthesis is essential to this organism, we can appreciate that targeting it would be a promising new strategy to combat these fungal infections. We provide evidence that one particular enzyme in the production process,\n            <jats:italic>Ca<\/jats:italic>\n            Rib1, would be most promising as an antifungal drug target, as it plays a central role in regulation and proves to be essential in a mouse model of systemic infection.\n          <\/jats:p>","DOI":"10.1128\/msphere.00714-20","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T13:40:42Z","timestamp":1596548442000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Molecular Elucidation of Riboflavin Production and Regulation in Candida albicans, toward a Novel Antifungal Drug Target"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9874-3659","authenticated-orcid":false,"given":"Liesbeth","family":"Demuyser","sequence":"first","affiliation":[{"name":"VIB-KU Leuven Center for Microbiology, Flanders, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Palmans","sequence":"additional","affiliation":[{"name":"VIB-KU Leuven Center for Microbiology, Flanders, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Vandecruys","sequence":"additional","affiliation":[{"name":"VIB-KU Leuven Center for Microbiology, Flanders, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-897X","authenticated-orcid":false,"given":"Patrick","family":"Van Dijck","sequence":"additional","affiliation":[{"name":"VIB-KU Leuven Center for Microbiology, Flanders, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2015.1091805"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0805-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.37"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009845107"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2018.1482181"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00030-10"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.02.018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.11.120"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2013.12.005"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00590-07"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.059972"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0421-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2010.00946.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo900768c"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo051332v"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910029690"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14829"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.06.053"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701724200"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw924"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2013.12.015"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/b210142b"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-1-29"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00201-17"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.110.3.818-822.1972"},{"key":"e_1_3_2_29_2","unstructured":"Priemer DS. 2018. 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