{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:09:16Z","timestamp":1790820556342,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI099080"],"award-info":[{"award-number":["R01AI099080"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,2,27]]},"abstract":"<jats:p>\n            Maintenance of Ca\n            <jats:sup>2+<\/jats:sup>\n            homeostasis is important for fungal cells to respond to a multitude of stresses, as well as antifungal treatment, and for virulence in animal models. Here, we demonstrate that a P-type ATPase, Pmc1p, is required for\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            <jats:named-content content-type=\"genus-species\">albicans<\/jats:named-content>\n            to respond to a variety of stresses, affects azole susceptibility, and is required to sustain tissue invasive hyphal growth and to cause disease in a mouse model of disseminated infection. Defining the mechanisms responsible for maintaining proper Ca\n            <jats:sup>2+<\/jats:sup>\n            homeostasis in this important human pathogen can ultimately provide opportunities to devise new chemotherapeutic interventions that dysregulate intracellular signaling and induce Ca\n            <jats:sup>2+<\/jats:sup>\n            toxicity.\n          <\/jats:p>","DOI":"10.1128\/msphere.00715-18","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T13:41:33Z","timestamp":1549374093000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["The Vacuolar Ca\n            <sup>2+<\/sup>\n            ATPase Pump Pmc1p Is Required for Candida albicans Pathogenesis"],"prefix":"10.1128","volume":"4","author":[{"given":"Arturo","family":"Luna-Tapia","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"DeJarnette","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology and Biochemistry, College of Graduate Health Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Sansevere","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker","family":"Reitler","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology and Biochemistry, College of Graduate Health Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Butts","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk E.","family":"Hevener","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen E.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.54.3.266-292.1990"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2008.09.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.147207"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37279-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.10.2343"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01528-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2017.05.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.308"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00519-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.5.2226"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2011.01.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.3.351"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12803"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00114-10"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12458"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037591"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.4.546"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03495.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.6.1868-1874.1999"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01034-16"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.1995_4900"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.5.1053-1060.2003"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80358-X"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5767-5774.2005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091014-104330"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.11.022"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.3.422-430.2003"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.24.3432"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309978200"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2011.01.010"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.02.026"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63860-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00041-3"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82197-4"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2477-2481.2002"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00084-17"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.129"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04239-14"},{"key":"e_1_3_2_40_2","volume-title":"Methods in yeast genetics: a cold spring harbor laboratory course manual","author":"Burke D","year":"2000","unstructured":"Burke D, Dawson D, Stearns T, Laboratory CSH. 2000. Methods in yeast genetics: a cold spring harbor laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.6.1425"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3791\/2437"},{"key":"e_1_3_2_43_2","volume-title":"CLSI document M27-A3","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard, 3rd ed. CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.4.718-728.2003"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00715-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00715-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:16:40Z","timestamp":1646713000000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00715-18"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2,27]]}},"alternative-id":["10.1128\/mSphere.00715-18"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00715-18","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00715-18"}}