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Individual patient costs may exceed $100,000 in the United States. All antifungals in current use have serious limitations due to host toxicity and\/or insufficient fungal cell killing that results in recurrent infections. Few new antifungal drugs have been introduced in the last 2 decades. Hence, there is a critical need for improved antifungal therapeutics. By targeting antifungal-loaded liposomes to \u03b1-mannans in the extracellular matrices secreted by these fungi, we dramatically reduced the effective dose of drug. Dectin-2-coated liposomes loaded with amphotericin B bound 50- to 150-fold more strongly to\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            than untargeted liposomes and killed these fungi more than an order of magnitude more efficiently. Targeting drug-loaded liposomes specifically to fungal cells has the potential to greatly enhance the efficacy of most antifungal drugs.\n          <\/jats:p>","DOI":"10.1128\/msphere.00715-19","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T11:15:54Z","timestamp":1572347754000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Dectin-2-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy"],"prefix":"10.1128","volume":"4","author":[{"given":"Suresh","family":"Ambati","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma C.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-8387","authenticated-orcid":false,"given":"Xiaorong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Meagher","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_2_3_2","unstructured":"CDC. 2018. 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