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Drug resistance in cholera results mainly from acquisition of mobile genetic elements. Genomic islands conferring multidrug resistance and mobilizable by IncC conjugative plasmids were reported to circulate in non-O1\/non-O139\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            clinical strains isolated from the 2010 Haitian cholera outbreak. As these genomic islands can be transmitted to pandemic\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            serogroups, their mechanism of transmission needed to be investigated. Our research revealed plasmid- and genomic island-encoded factors required for the resistance island excision, mobilization, and integration, as well as regulation of these functions. The discovery of related genomic islands carrying diverse phage resistance genes but lacking antibiotic resistance-conferring genes in a wide range of marine dwelling bacteria suggests that these elements are ancient and recently acquired drug resistance genes.\n          <\/jats:p>","DOI":"10.1128\/msphere.00748-20","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T13:01:12Z","timestamp":1598360472000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Antibiotic Resistance in Vibrio cholerae: Mechanistic Insights from IncC Plasmid-Mediated Dissemination of a Novel Family of Genomic Islands Inserted at\n            <i>trmE<\/i>"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-5438","authenticated-orcid":false,"given":"Nicolas","family":"Rivard","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biologie, 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