{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:40:26Z","timestamp":1790991626692,"version":"4.1.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI130170"],"award-info":[{"award-number":["R01AI130170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,8,26]]},"abstract":"<jats:p>\n            The newly emerged\n            <jats:italic>Candida<\/jats:italic>\n            species\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            has been associated with an exponential rise in invasive disease in health care facilities worldwide with a mortality rate approaching 60%.\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            exhibits a high level of transmissibility, multidrug resistance, and persistence in hospital environments, yet little is known about its pathogenesis largely due to limited data from animal studies. We used clinically relevant murine models of infection to comparatively evaluate the host niche-specific pathogenic potential of\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            . Findings demonstrated that\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            adheres more avidly, forming robust biofilms on catheters implanted in mice. However, although\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            adhered to oral tissue\n            <jats:italic>ex vivo<\/jats:italic>\n            , it failed to colonize the oral cavity\n            <jats:italic>in vivo<\/jats:italic>\n            . In contrast, in the intraperitoneal infection model,\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            persisted longer in the peritoneal cavity and kidneys. Understanding the host-pathogen factors contributing to the rise of\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            as a nosocomial pathogen is critical for controlling the spread of this species.\n          <\/jats:p>","DOI":"10.1128\/msphere.00760-20","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T14:39:00Z","timestamp":1596724740000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-4367","authenticated-orcid":false,"given":"Taissa","family":"Vila","sequence":"first","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-4277","authenticated-orcid":false,"given":"Daniel","family":"Montelongo-Jauregui","sequence":"additional","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussian","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taanya","family":"Puthran","sequence":"additional","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-4562","authenticated-orcid":false,"given":"Ahmed S.","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-3873","authenticated-orcid":false,"given":"Mary Ann","family":"Jabra-Rizk","sequence":"additional","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Brown JL Delaney C Short B Butcher MC McKloud E Williams C Kean R Ramage G. 2020. 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