{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:24:22Z","timestamp":1791239062664,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM099530"],"award-info":[{"award-number":["R01GM099530"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,2,26]]},"abstract":"<jats:p>\n                    Porphyrins are a group of metabolites essential to the biosynthesis of heme, cobalamin, and chlorophyll in living organisms. Bacterial porphyrins can be proinflammatory, with high levels linked to human inflammatory diseases, including the common skin condition acne vulgaris. Propionibacteria are among the most abundant skin bacteria. Variations in propionibacteria composition on the skin may lead to different porphyrin levels and inflammatory potentials. This study characterized porphyrin production in all lineages of\n                    <jats:named-content content-type=\"genus-species\">Propionibacterium acnes<\/jats:named-content>\n                    , the most dominant skin\n                    <jats:italic>Propionibacterium<\/jats:italic>\n                    , and other resident skin propionibacteria, including\n                    <jats:italic>P. granulosum<\/jats:italic>\n                    ,\n                    <jats:italic>P. avidum<\/jats:italic>\n                    , and\n                    <jats:italic>P. humerusii<\/jats:italic>\n                    . We revealed that\n                    <jats:named-content content-type=\"genus-species\">P. acnes<\/jats:named-content>\n                    type I strains produced significantly more porphyrins than did type II and III strains and other\n                    <jats:italic>Propionibacterium<\/jats:italic>\n                    species. The findings from this study shed light on the proinflammatory potential of the skin microbiome and can be used to guide the development of effective acne treatments by modulating the skin microbiome and its metabolic activities.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00793-19","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T08:14:50Z","timestamp":1578989690000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Porphyrin Production and Regulation in Cutaneous Propionibacteria"],"prefix":"10.1128","volume":"5","author":[{"given":"Emma","family":"Barnard","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tremylla","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Ngo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Leuterio","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McDowell","sequence":"additional","affiliation":[{"name":"Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"},{"name":"UCLA-DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.03.018"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9673(00)91640-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/285017a0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0088"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01286-14"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06530.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00023-15"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab2009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/918320"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00413361"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1011-1344(97)00039-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep39491"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00479-12"},{"key":"e_1_3_2_16_2","first-page":"1165","article-title":"Acne caused by vitamin B12","volume":"221","author":"Dugois P","year":"1969","unstructured":"Dugois P, Amblard P, Imbert R, de Bignicourt B. 1969. Acne caused by vitamin B12. Lyon Med 221:1165. (In French.)","journal-title":"Lyon Med"},{"key":"e_1_3_2_17_2","first-page":"210","article-title":"Vitamin B-12 induced acnes","volume":"24","author":"Dupr\u00e9 A","year":"1979","unstructured":"Dupr\u00e9 A, Albarel N, Bonafe JL, Christol B, Lassere J. 1979. Vitamin B-12 induced acnes. Cutis 24:210\u2013211.","journal-title":"Cutis"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.35.1.62-66.1978"},{"key":"e_1_3_2_19_2","first-page":"976","article-title":"Wood lamp examination","volume":"58","author":"Ponka D","year":"2012","unstructured":"Ponka D, Baddar F. 2012. Wood lamp examination. 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