{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:51:21Z","timestamp":1787921481826,"version":"build-2784847793"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI119448"],"award-info":[{"award-number":["AI119448"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1013362.02"],"award-info":[{"award-number":["1013362.02"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"DOD | Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["HR001118S0041"],"award-info":[{"award-number":["HR001118S0041"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010559","name":"Pitt | University of Pittsburgh Medical Center | Children's Hospital of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>Animal models of viral disease are very important for understanding how viruses make people sick and for testing out drugs and vaccines to see if they can prevent disease. In this study, we identify the ferret as a model of encephalitis caused by Rift Valley fever virus (RVFV). This novel model will allow researchers to evaluate ways to prevent RVFV encephalitis.<\/jats:p>","DOI":"10.1128\/msphere.00798-20","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T14:09:47Z","timestamp":1603807787000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Rift Valley Fever Virus Infection Causes Acute Encephalitis in the Ferret"],"prefix":"10.1128","volume":"5","author":[{"given":"Dominique J.","family":"Barbeau","sequence":"first","affiliation":[{"name":"University of Pittsburgh, School of Medicine, Department of Pediatrics, Division of Pediatric infectious Disease, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Albe","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Public Health, Department of Infectious Disease and Microbiology, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sham","family":"Nambulli","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha L.","family":"Tilston-Lunel","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-2973","authenticated-orcid":false,"given":"Amy L.","family":"Hartman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Public Health, Department of Infectious Disease and Microbiology, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema S.","family":"Lakdawala","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Klein","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine, Division of Laboratory Animal Research, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Paul","family":"Duprex","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-7536","authenticated-orcid":false,"given":"Anita K.","family":"McElroy","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine, Department of Pediatrics, Division of Pediatric infectious Disease, Pittsburgh, Pennsylvania, USA"},{"name":"University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0290"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001265"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105.6.124"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2008.0108"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/378747"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0318"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3402\/iee.v5.28024"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003584"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003548"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.07.005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/v3050493"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.10.023"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.08.016"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01962"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000949"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(87)90126-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00105"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890100107"},{"key":"e_1_3_2_20_2","first-page":"60","article-title":"Experimental Rift Valley fever encephalitis in ACI rats","volume":"3","author":"Bucci TJ","year":"1981","unstructured":"Bucci TJ, Moussa IM, Wood OL. 1981. Experimental Rift Valley fever encephalitis in ACI rats. Control Epidemiol Biostat 3:60\u201367.","journal-title":"Control Epidemiol Biostat"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007833"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.10.021"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00651"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.01.016"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116722"},{"key":"e_1_3_2_26_2","first-page":"37988","article-title":"New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Final Rule","volume":"67","author":"Federal Register","year":"2002","unstructured":"Federal Register. 2002. New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Final Rule. Fed Regist 67:37988\u201337998.","journal-title":"Fed Regist"},{"key":"e_1_3_2_27_2","volume-title":"Guidance for industry: animal models\u2014essential elements to address efficacy under the animal rule","author":"FDA","year":"2009","unstructured":"FDA. 2009. Guidance for industry: animal models\u2014essential elements to address efficacy under the animal rule. Food and Drug Administration, Washington, DC."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02341-13"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311021"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06190-11"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.017"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw209"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01033-16"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17694"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12687"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.62.3.433"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau9812"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2012.10.003"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0392-3"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00337-13"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01270-18"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2017.01.004"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002874"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311288"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002790"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02501-07"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01509"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00215-08"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01662-17"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.09.035"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a118408"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00936-07"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-0166-9"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00798-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00798-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:39:28Z","timestamp":1646714368000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00798-20"}},"subtitle":[],"editor":[{"given":"Rebecca Ellis","family":"Dutch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10,28]]}},"alternative-id":["10.1128\/mSphere.00798-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00798-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2020-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00798-20"}}