{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:41:11Z","timestamp":1790419271043,"version":"4.1.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["T.0255.16"],"award-info":[{"award-number":["T.0255.16"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["T.0255.16"],"award-info":[{"award-number":["T.0255.16"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,2,26]]},"abstract":"<jats:p>\n            While the GAS M protein has been the leading vaccine target for decades, the bacteria encode many other virulence factors of interest for vaccine development. In this work, we show that\n            <jats:italic>emm<\/jats:italic>\n            -like genes are encoded in a remarkable majority of GAS genomes and expressed at a level similar to that for the\n            <jats:italic>emm<\/jats:italic>\n            gene. In collaboration with the U.S. Centers for Disease Control, we developed molecular definitions of the different\n            <jats:italic>emm<\/jats:italic>\n            and\n            <jats:italic>emm<\/jats:italic>\n            -like gene families. This clarification should abrogate mistyping of strains, especially in the area of whole-genome typing. We have also updated the\n            <jats:italic>emm<\/jats:italic>\n            -typing collection by removing\n            <jats:italic>emm<\/jats:italic>\n            -like gene sequences and provided in-depth analysis of Mrp and Enn protein sequence structure and diversity.\n          <\/jats:p>","DOI":"10.1128\/msphere.00806-19","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T13:06:27Z","timestamp":1578402387000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Analysis of Global Collection of Group A\n            <i>Streptococcus<\/i>\n            Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins"],"prefix":"10.1128","volume":"5","author":[{"given":"Hannah R.","family":"Frost","sequence":"first","affiliation":[{"name":"Molecular Bacteriology Laboratory, Universit\u00e9 Libre de Bruxelles, Brussels, 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