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In the last 2 decades, the increasing number of azole-resistant\n            <jats:named-content content-type=\"genus-species\">C. parapsilosis<\/jats:named-content>\n            clinical isolates has been attributable to the overuse and misuse of fluconazole, the first-line antifungal agent most commonly used in several countries. To date, the range of applicable antifungal drugs is limited. As a consequence, it is essential to understand the possible mechanisms of antifungal resistance development and their effect on virulence in order to optimize antifungal treatment strategies in the clinical setting. Our results revealed that the prolonged exposure to azoles resulted not only in azole resistance but also in cross-resistance development. Our data further indicate that resistance development may occur through different mechanisms that can also alter the virulence of\n            <jats:named-content content-type=\"genus-species\">C. parapsilosis<\/jats:named-content>\n            . These results highlight the consequences of prolonged drug usage and suggest the need for developing alternative antifungal treatment strategies in clinical practice.\n          <\/jats:p>","DOI":"10.1128\/msphere.00821-20","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T14:09:47Z","timestamp":1603807787000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Triazole Evolution of Candida parapsilosis Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner"],"prefix":"10.1128","volume":"5","author":[{"given":"Csaba","family":"Papp","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, 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