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For both, nasal colonization is a risk factor for infection. Studies of nasal microbiota identify\n                    <jats:named-content content-type=\"genus-species\">Dolosigranulum pigrum<\/jats:named-content>\n                    as a benign bacterium present when adults are free of\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    or when children are free of\n                    <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n                    . Here, we validated these\n                    <jats:italic>in vivo<\/jats:italic>\n                    associations with functional assays. We found that\n                    <jats:named-content content-type=\"genus-species\">D. pigrum<\/jats:named-content>\n                    inhibited\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    <jats:italic>in vitro<\/jats:italic>\n                    and, together with a specific nasal\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    species, also inhibited\n                    <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n                    . Furthermore, genomic analysis of\n                    <jats:named-content content-type=\"genus-species\">D. pigrum<\/jats:named-content>\n                    indicated that it must obtain key nutrients from other nasal bacteria or from humans. These phenotypic interactions support the idea of a role for microbe-microbe interactions in shaping the composition of human nasal microbiota and implicate\n                    <jats:named-content content-type=\"genus-species\">D. pigrum<\/jats:named-content>\n                    as a mutualist of humans. These findings support the feasibility of future development of microbe-targeted interventions to reshape nasal microbiota composition to exclude\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    and\/or\n                    <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/msphere.00852-20","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T10:26:30Z","timestamp":1599560790000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":141,"title":["Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota"],"prefix":"10.1128","volume":"5","author":[{"given":"Silvio D.","family":"Brugger","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA"},{"name":"Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Eslami","sequence":"additional","affiliation":[{"name":"The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda M.","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel F.","family":"Escapa","sequence":"additional","affiliation":[{"name":"The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA"},{"name":"Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA"},{"name":"Alkek Center for Metagenomics &amp; Microbiome Research, Department of Molecular Virology &amp; Microbiology, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Henke","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry and W.M. 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