{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:45:40Z","timestamp":1767991540773,"version":"3.49.0"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI144036"],"award-info":[{"award-number":["K23AI144036"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>\n            Fecal microbiota transplantation (FMT), which is highly efficacious in treating recurrent\n            <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n            infection (RCDI), has a promising application in decolonization of multidrug-resistant organisms, reduction of antibiotic resistance gene abundance, and restoration of healthy intestinal microbiota. However, data representing clinical microbiology results after FMT are limited. We sought to characterize the differences in culture positivity and antimicrobial susceptibility profiles in patients with Gram-negative infections in the year before and the year after FMT for RCDI. Drawing on prior studies that had demonstrated the success of FMT in eradicating extraintestinal infections and the occurrence of patient-level interspecies transfer of resistance elements, we employed an agnostic analytic approach of reviewing the data irrespective of body site or species. In a small RCDI population, we observed an improvement in the antimicrobial susceptibility profile of Gram-negative bacteria following FMT, which supports further study of FMT as a strategy to combat antibiotic resistance.\n          <\/jats:p>","DOI":"10.1128\/msphere.00853-20","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T13:21:07Z","timestamp":1602595267000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Gram-Negative Taxa and Antimicrobial Susceptibility after Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection"],"prefix":"10.1128","volume":"5","author":[{"given":"Danielle Barrios","family":"Steed","sequence":"first","affiliation":[{"name":"Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Wang","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyanshu","family":"Raheja","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex D.","family":"Waldman","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-4871","authenticated-orcid":false,"given":"Ahmed","family":"Babiker","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvi","family":"Dhere","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Department of Medicine, Division of Digestive Diseases, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1757-8477","authenticated-orcid":false,"given":"Colleen S.","family":"Kraft","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, USA"},{"name":"Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-4599","authenticated-orcid":false,"given":"Michael H.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Antimicrobial resistance 2014 global report on surveillance","author":"World Health Organization (WHO)","year":"2014","unstructured":"World Health Organization (WHO). 2014 Antimicrobial resistance 2014 global report on surveillance. 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