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Upon infection of a new cell,\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    establishes a replicative vacuole and translocates parasite effectors across this vacuole to function from the host cytosol and nucleus. These effectors play a key role in parasite virulence. The work reported here newly identifies three parasite proteins that are necessary for protein translocation into the host cell. 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