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Despite recent discoveries of the roles of ATP and membrane potential in persister formation, the key element that triggers change of ATP or membrane potential remains elusive. Our work demonstrates that Mg\n            <jats:sup>2+<\/jats:sup>\n            instead of other ions or nutrient components is the key element for persistence by inducing a decrease of cytoplasmic ATP, which subsequently induces persister formation. In addition, we observed tight regulation of genes for Mg\n            <jats:sup>2+<\/jats:sup>\n            transport in different growth phases in\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            . These findings indicate that despite being a key nutrient, Mg\n            <jats:sup>2+<\/jats:sup>\n            also served as a key signal in persister formation during growth.\n          <\/jats:p>","DOI":"10.1128\/msphere.00862-19","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T13:06:50Z","timestamp":1578402410000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-5799","authenticated-orcid":false,"given":"Tao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Key Laboratory of Medical Molecular Virology (MOE\/MOH) and 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