{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:40:05Z","timestamp":1785400805088,"version":"3.56.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Fungal infections remain a major global human health problem, responsible for billions of infections and millions of deaths each year. Dissecting the immune mechanisms that protect us against these infections is an important step toward developing alternative therapies for patients at risk for fungal diseases, who are typically immunocompromised. Understanding antifungal immune responses is complicated by heterogeneity within host cell populations, as well as in-host adaptation strategies employed by fungi, which may also drive multiple distinct populations during infection. In this article, I discuss our recent discoveries and that of the medical mycology field, which has used creative and interdisciplinary approaches to better define the multiple layers of complexity that influence host\u2013fungal interactions and infection outcomes. Finally, I describe examples where fundamental discovery has translated into new treatment approaches for patients and may represent revolutionary changes for our growing field.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msphere.00873-25","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:00:44Z","timestamp":1780059644000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Hidden battles: dissecting host\u2013fungal interactions and immune heterogeneity in infection outcomes"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-7074","authenticated-orcid":true,"given":"Rebecca A.","family":"Drummond","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03angcq70","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Immunology and Immunotherapy, School of Infection, Inflammation and Immunity, College of Medical and Health Sciences, University of Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.003"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64034-5"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2025.11.008"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201846171"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25590-8"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00078-25"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.08.017"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43061-0"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6550"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30103-8"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi3363"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116465"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17625"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0377-2"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-025-02122-4"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07142-4"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-68863-w"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.04.031"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09882-3"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-02015-4"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01643-9"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88782"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5731"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312665"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01774-25"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00873-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00873-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:02:43Z","timestamp":1783688563000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00873-25"}},"subtitle":[],"editor":[{"given":"Ira J.","family":"Blader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,30]]}},"alternative-id":["10.1128\/msphere.00873-25"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00873-25","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2026-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00873-25"}}