{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:53Z","timestamp":1787016773714,"version":"build-2736575974"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100012372","name":"SDSU | South Dakota Agricultural Experiment Station","doi-asserted-by":"publisher","award":["Animal Health and Hatch Funds"],"award-info":[{"award-number":["Animal Health and Hatch Funds"]}],"id":[{"id":"10.13039\/100012372","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>\n                    Bats host a large numbers of viruses, many of which are zoonotic. In the United States, the big brown bat (\n                    <jats:named-content content-type=\"genus-species\">Eptesicus fuscus<\/jats:named-content>\n                    ) is widely distributed and lives in small colonies that roost in cavities, often in human dwellings, leading to frequent human interaction. Viral metagenomic sequencing of samples from an\n                    <jats:named-content content-type=\"genus-species\">E. fuscus<\/jats:named-content>\n                    bat submitted for rabies testing identified the first exogenous bat\n                    <jats:italic>Deltaretrovirus<\/jats:italic>\n                    . The\n                    <jats:named-content content-type=\"genus-species\">E. fuscus<\/jats:named-content>\n                    deltaretrovirus (EfDRV) genome consists of the typical deltaretrovial 5\u2032-\n                    <jats:italic>gag<\/jats:italic>\n                    -\n                    <jats:italic>pro<\/jats:italic>\n                    -\n                    <jats:italic>pol<\/jats:italic>\n                    -\n                    <jats:italic>env<\/jats:italic>\n                    -3\u2032 genes along with genes encoding two putative transcriptional transactivator proteins distantly related to the Tax protein of human T-cell lymphotrophic virus and nuclear antigen 3B of Epstein-Barr virus. Searches of the\n                    <jats:named-content content-type=\"genus-species\">E. fuscus<\/jats:named-content>\n                    genome sequence failed to identify endogenous EfDRV. RT-PCR targeting the EfDRV\n                    <jats:italic>pol<\/jats:italic>\n                    gene identified 4\/60 (6.7%) bats with positive results. Together, these results suggest that EfDRV is exogenous. As all members of\n                    <jats:italic>Deltaretrovirus<\/jats:italic>\n                    are associated with T- and B-cell malignancies or neurologic disease, further studies on possible zoonosis are warranted.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00902-20","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T09:55:19Z","timestamp":1600768519000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["North American Big Brown Bats (Eptesicus fuscus) Harbor an Exogenous\n                    <i>Deltaretrovirus<\/i>"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-4676","authenticated-orcid":false,"given":"Ben M.","family":"Hause","sequence":"first","affiliation":[{"name":"Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, South Dakota, USA"},{"name":"Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, South Dakota, USA"},{"name":"Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Christopher-Hennings","sequence":"additional","affiliation":[{"name":"Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, South Dakota, USA"},{"name":"Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00017-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0394-z"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200092"},{"key":"e_1_3_2_5_2","unstructured":"Stoye JP Blomberg J Coffin JM Fan H Hahn B Neil J Quackenbush S Rethwilm A Tristem M. 2011. 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International Committee on Taxonomy of Viruses ninth report. https:\/\/talk.ictvonline.org\/ictv-reports\/ictv_9th_report\/reverse-transcribing-dna-and-rna-viruses-2011\/w\/rt_viruses\/161\/retroviridae."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.5955-5966.1998"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2001-2-6-reviews1017"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-018-0458-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920346117"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2003.08.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2014.11.014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31169"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.256.2.195"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121998"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.65.3.1466-1478.1991"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621224114"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a003851"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-019-0495-9"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915400117"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-35"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.043760-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80547-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04841"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1988.tb14518.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01871-17"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00137-4"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00902-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00902-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:43:42Z","timestamp":1646696622000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00902-20"}},"subtitle":[],"editor":[{"given":"James M.","family":"Pipas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10,28]]}},"alternative-id":["10.1128\/mSphere.00902-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00902-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2020-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00902-20"}}