{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:54:16Z","timestamp":1773388456696,"version":"3.50.1"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2017\/1666741"],"award-info":[{"award-number":["2017\/1666741"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/03654-0"],"award-info":[{"award-number":["2016\/03654-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>HTLV-1 and HTLV-2 are endemic to Brazil, and they have different effects in HIV\/AIDS disease progression. HIV\/HTLV-1 has been described as accelerating the progression to AIDS and death, while HIV\/HTLV-2 slows the progression to AIDS. Provirus mutations of HTLV-1 were implicated in severe leukemia development and in problems in the diagnosis of HTLV-1; in contrast, provirus mutations of HTLV-2 had not been confirmed and associated with problems in HTLV-2 diagnosis or disease outcome. Nevertheless, data obtained here allowed us to recognize and understand the false-negative results in serologic and molecular tests applied for HTLV-1 and HTLV-2 diagnosis. Defective proviruses, as well as synonymous and nonsynonymous mutations, were associated with the diagnosis deficiencies. Additionally, since HIV-1 and HTLV-1 infect the same cells (CD4 positive), the production of HIV-1 pseudotypes with HTLV-1 envelope glycoprotein during HIV\/HTLV-1 coinfection cannot be excluded. Defective provirus of HTLV-2 and Tax2c is speculated to influence progression to AIDS.<\/jats:p>","DOI":"10.1128\/msphere.00923-20","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T13:56:17Z","timestamp":1601387777000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Provirus Mutations of Human T-Lymphotropic Virus 1 and 2 (HTLV-1 and HTLV-2) in HIV-1-Coinfected Individuals"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-1937","authenticated-orcid":false,"given":"Karoline Rodrigues","family":"Campos","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em HTLV, Centro de Imunologia, Instituto Adolfo Lutz, Coordenadoria de Controle de Doen\u00e7as, Secretaria de Estado da Sa\u00fade, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-6580","authenticated-orcid":false,"given":"Adele","family":"Caterino-de-Araujo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em HTLV, Centro de Imunologia, Instituto Adolfo Lutz, Coordenadoria de Controle de Doen\u00e7as, Secretaria de Estado da Sa\u00fade, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6981847"},{"key":"e_1_3_2_4_2","first-page":"4738","article-title":"Kyoto Workshop on some specific recent advances in human tumor virology (meeting report)","volume":"41","author":"Gallo RC","year":"1981","unstructured":"Gallo RC, de-Th\u00e9 GB, Ito Y. 1981. Kyoto Workshop on some specific recent advances in human tumor virology (meeting report). Cancer Res 41:4738\u20134739.","journal-title":"Cancer Res"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/300063a0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90446-x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17479.1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6189183"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411153112006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3008335"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03370220095034"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91047-X"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(87)91172-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2111"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(85)92734-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02563"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.20.9525-9531.2000"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02511-06"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.016"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-016-0156-4"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25450"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-1702(02)00276-9"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00659-17"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0647"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2017.02.005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0014"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-311x2003000400013"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652015000100001"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093374"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.12.005"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-535"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-184"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.01.015"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2013.0181"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1993.0074"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(02)01156-3"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/3.2.125"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20775"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21718"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00038-18"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2011.0342"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200110190-00023"},{"key":"e_1_3_2_47_2","first-page":"8","article-title":"HIV\/Human T-cell lymphotropic virus coinfection revisited: impact on AIDS progression","volume":"11","author":"Brites C","year":"2009","unstructured":"Brites C, Sampalo J, Oliveira A. 2009. HIV\/Human T-cell lymphotropic virus coinfection revisited: impact on AIDS progression. AIDS Rev 11:8\u201316.","journal-title":"AIDS Rev"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1752117"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.22.953"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0074-02762006000300008"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2011.0389"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/v3050541"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-11-S1-P110"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2010.0121"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2011.0117"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-3-20"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3618"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00923-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00923-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:42:48Z","timestamp":1646714568000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00923-20"}},"subtitle":[],"editor":[{"given":"Akira","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10,28]]}},"alternative-id":["10.1128\/mSphere.00923-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00923-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2020-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00923-20"}}