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Host genetic susceptibility plays a crucial role in the infection process of\n              <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n              (\n              <jats:italic>M. tuberculosis<\/jats:italic>\n              ) with single nucleotide polymorphisms (SNPs) identified as key factors in the genetic loci associated with tuberculosis occurrence and progression. Research indicates that polymorphisms in cytokine genes\u2014including interferons, interleukins, tumor necrosis factors, and chemokines\u2014are closely linked to the onset, progression, and treatment outcomes of pulmonary tuberculosis. Investigating cytokine gene polymorphisms in PTB patients is essential for understanding disease mechanisms and prognosis. This review summarizes the role of cytokine polymorphisms in tuberculosis morbidity, elucidates the biological genetic mechanisms involved at the molecular level, and provides insights into clinical treatment strategies for TB.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/msphere.00944-24","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T16:19:36Z","timestamp":1744647576000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Advances in cytokine gene polymorphisms in tuberculosis"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4847-0284","authenticated-orcid":false,"given":"Haiyang","family":"Fu","sequence":"first","affiliation":[{"name":"Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong)","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong)","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9364-595X","authenticated-orcid":false,"given":"Ye","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Dalian Municipal Women and Children\u2019s Medical Center","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-019-01612-5"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06258"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20171121"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2017.06.002"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0475-2016"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.16-00250-5"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.11.010"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60050685"},{"key":"e_1_3_1_10_2","volume-title":"Global tuberculosis report 2022","author":"World Health Organization","year":"2022","unstructured":"World Health Organization. 2022. 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