{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:48Z","timestamp":1787016768678,"version":"build-2736575974"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"\n Kathy Shair works in the field of Epstein-Barr virus (EBV)-associated cancers, with emphasis on nasopharyngeal carcinoma (NPC). In this mSphere of Influence article, she reflects on how the paper \u201cEfficient replication of Epstein-Barr virus in stratified epithelium\n in vitro<\/jats:italic>\n \u201d by Temple et al. (R. M. Temple, J. Zhu, L. Budgeon, N. D. Christensen, et al., Proc Natl Acad Sci U S A 111:16544\u201316549, 2014,\n https:\/\/doi.org\/10.1073\/pnas.1400818111<\/jats:ext-link>\n ) has influenced her work on EBV molecular pathogenesis in the nasopharynx by highlighting the importance of using three-dimensional (3-D) culture models to study epithelial infection.\n <\/jats:p>","DOI":"10.1128\/msphere.00954-20","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T09:56:17Z","timestamp":1601373377000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["mSphere of Influence: 3-D Culture Models Influence Studies on Epstein-Barr Virus Molecular Pathogenesis in the Epithelium"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-1745","authenticated-orcid":false,"given":"K. H. Y.","family":"Shair","sequence":"first","affiliation":[{"name":"Cancer Virology Program, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"},{"name":"Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405103101905"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400818111"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005195"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10040086"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0602-594"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6655-4_4"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.22.12613-12624.2004"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01332-19"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01216-18"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.05.005"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910260202"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23374"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06889-5"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05625"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphereDirect.00453-17"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00152-18"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02438-16"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0034-7"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0436-5"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523436113"},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","unstructured":"Ziegler P Bai Y Tian Y Abrahamsson S Green A Moore J Lee SE Myerburg MM Park HJ Tang K-W Shair KHY. 2020. A three-dimensional air-liquid interface culture model for the study of Epstein-Barr virus infection in the nasopharynx. bioRxiv doi:10.1101\/2020.08.31.272096.","DOI":"10.1101\/2020.08.31.272096"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00954-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00954-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:44:06Z","timestamp":1646696646000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00954-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10,28]]}},"alternative-id":["10.1128\/mSphere.00954-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00954-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2020-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00954-20"}}