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The Centers for Disease Control and Prevention (CDC) have classified\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    as an urgent threat to public health for the next decade due to its major clinical and economic impact and the lack of effective antifungal drugs and because of future projections concerning new\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    infections. Importantly, the Global Antimicrobial Resistance Surveillance System (GLASS) has highlighted the need for more robust and efficacious global surveillance schemes enabling the identification and monitoring of antifungal resistance in\n                    <jats:italic>Candida<\/jats:italic>\n                    infections. Despite the clinical relevance of\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    infections, our overall understanding of its pathophysiology and virulence, its response to human immune surveillance, and the molecular basis of multiple antifungal resistance remains in its infancy. Here, we show a marked phenotypic plasticity of\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    clinical isolates. Further, we demonstrate critical roles of stress response mechanisms in regulating multidrug resistance and show that cell wall architecture and composition are key elements that determine antifungal drug susceptibilities. Our data promise new therapeutic options to treat drug-refractory\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    infections.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00973-20","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T09:21:07Z","timestamp":1602580867000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["The Two-Component Response Regulator Ssk1 and the Mitogen-Activated Protein Kinase Hog1 Control Antifungal Drug Resistance and Cell Wall Architecture of Candida auris"],"prefix":"10.1128","volume":"5","author":[{"given":"Raju","family":"Shivarathri","sequence":"first","affiliation":[{"name":"Public Health Research Institute, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Jenull","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Department of Medical Biochemistry, Max Perutz Labs Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Stoiber","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Department of Medical Biochemistry, Max Perutz Labs Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rounik","family":"Mazumdar","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Department of Medical Biochemistry, Max Perutz Labs Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Department of Medical Biochemistry, Max Perutz Labs Vienna, Vienna, Austria"},{"name":"CCRI\u2014St. Anna Children's Cancer Research Institute, Vienna, Austria"},{"name":"Labdia\u2014Labordiagnostik GmbH, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-5955","authenticated-orcid":false,"given":"Karl","family":"Kuchler","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Department of Medical Biochemistry, Max Perutz Labs Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-7462","authenticated-orcid":false,"given":"Anuradha","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-9897","authenticated-orcid":false,"given":"Neeraj","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"},{"name":"Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy358"},{"key":"e_1_3_2_4_2","volume-title":"Candida and candidiasis","author":"Calderone RA","year":"2002","unstructured":"Calderone RA. 2002. 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