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The genetic determinants of extended-spectrum cephalosporin and fluoroquinolone resistance were highly diverse, with multiple plasmids, insertion sequences, and genes playing key roles in mediating resistance in swine\n                    <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n                    . Plasmids assembled in this study are known to be disseminated globally in both human and animal populations and environmental samples, and\n                    <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n                    in pigs might be part of a global reservoir of key antimicrobial resistance (AMR) elements. Virulent plasmids found in this study have been shown to confer fitness advantages to pathogenic\n                    <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n                    strains. 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