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Alarmingly, ZIKV infection has been associated with neurological complications such as Guillain-Barr\u00e9 syndrome (GBS) in adults and congenital fetal growth-associated anomalies in newborns. Host peripheral immune cells are one of the first to interact with the virus upon successful transmission from an infected female\n                    <jats:italic>Aedes<\/jats:italic>\n                    mosquito. However, little is known about the role of these immune cells during infection. In this work, the immune responses of monocytes, known target cells of ZIKV infection, were investigated by high-density transcriptomics. The analysis saw a robust immune response being elicited. Importantly, it also divulged that monocytes prime NK cell activities during virus infection. Removal of monocytes during the infection changed the immune milieu, which in turn reduced NK cell stimulation. This study provides valuable insights into the pathobiology of the virus and allows for the possibility of designing novel targeted therapeutics.\n                  <\/jats:p>","DOI":"10.1128\/mspheredirect.00120-18","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T06:07:43Z","timestamp":1522130863000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and\/or NK Cell Activity"],"prefix":"10.1128","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5645-7048","authenticated-orcid":false,"given":"Fok-Moon","family":"Lum","sequence":"first","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Kwang","family":"Chua","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeslin J. 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