{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:39:47Z","timestamp":1788845987003,"version":"build-2803163510"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NAWI Graz"},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P22986"],"award-info":[{"award-number":["P22986"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P27654"],"award-info":[{"award-number":["P27654"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["W901"],"award-info":[{"award-number":["W901"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,6,27]]},"abstract":"<jats:p>\n            The waterborne diarrheal disease cholera is caused by the bacterium\n            <jats:named-content content-type=\"genus-species\">Vibrio cholerae<\/jats:named-content>\n            . The facultative human pathogen persists as a natural inhabitant in the aquatic ecosystem between outbreaks. In contrast to the human host,\n            <jats:named-content content-type=\"genus-species\">V.\u00a0cholerae<\/jats:named-content>\n            requires a different set of genes to survive in this hostile environment. For example, predatory micrograzers are commonly found in the aquatic environment and use bacteria as a nutrient source, but knowledge of the interaction between bacterivorous grazers and\n            <jats:named-content content-type=\"genus-species\">V.\u00a0cholerae<\/jats:named-content>\n            is limited. In this study, we successfully adapted a genetic reporter technology and identified more than 100 genes activated by\n            <jats:named-content content-type=\"genus-species\">V.\u00a0cholerae<\/jats:named-content>\n            upon exposure to the bacterium-grazing nematode\n            <jats:named-content content-type=\"genus-species\">Caenorhabditis elegans<\/jats:named-content>\n            . This screen provides a first glimpse into responses and adaptational strategies of the bacterial pathogen against such natural predators. Subsequent phenotypic characterization revealed the mannose-sensitive hemagglutinin to be crucial for colonization of the worm, which causes developmental delay and growth retardation.\n          <\/jats:p>","DOI":"10.1128\/mspheredirect.00238-18","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T09:37:47Z","timestamp":1526981867000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Genes Activated by\n            <i>Vibrio cholerae<\/i>\n            upon Exposure to\n            <i>Caenorhabditis elegans<\/i>\n            Reveal the Mannose-Sensitive Hemagglutinin To Be Essential for Colonization"],"prefix":"10.1128","volume":"3","author":[{"given":"Cornelia","family":"List","sequence":"first","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Grutsch","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Radler","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Cakar","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz G.","family":"Zingl","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Schild-Pr\u00fcfert","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schild","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz, Graz, Austria"},{"name":"BioTechMed-Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60436-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.VMBF-0015-2015"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbe.3.131.1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2204"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15328-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1207"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05096.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5295.2025"},{"key":"e_1_3_3_10_2","first-page":"285","article-title":"Infectious disease and environment: cholera as a paradigm for waterborne disease","volume":"7","author":"Colwell RR","year":"2004","unstructured":"Colwell RR. 2004. Infectious disease and environment: cholera as a paradigm for waterborne disease. Int Microbiol 7:285\u2013289.","journal-title":"Int Microbiol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00375"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2007.01238.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011558"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601754103"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038200"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.573832"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.09.004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.05.011"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1138"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.7.3220-3225.2001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(91)90039-D"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)90852-4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb00406.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.06.037"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-2229.2009.00128.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2007.12.011"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecss.2009.11.034"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2011.02627.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2016.05.012"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.05.011"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2405-2407.2004"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.3733-3739.1999"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308707101"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.11.3606-3609.1999"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2008.04.005"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120096"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04249"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_3_3_39_2","first-page":"587","volume-title":"The nematode Caenorhabditis elegans. Cold Spring Harbor monograph series 17","author":"Sulston J","year":"1988","unstructured":"Sulston J, Hodgkin J. 1988. Methods, p 587\u2013606. In Wood WB (ed), The nematode Caenorhabditis elegans. Cold Spring Harbor monograph series 17. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07867.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.12.4310-4317.1991"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2634"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705636104"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj102"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm882"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1020"}],"container-title":["mSphere"],"original-title":[],"contributor":[{"given":"Paula","family":"Watnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Sun Nyunt","family":"Wai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Michael","family":"Steinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphereDirect.00238-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphereDirect.00238-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:14:47Z","timestamp":1646712887000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphereDirect.00238-18"}},"subtitle":[],"editor":[{"given":"Sarah E. F.","family":"D\u2019Orazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,27]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6,27]]}},"alternative-id":["10.1128\/mSphereDirect.00238-18"],"URL":"https:\/\/doi.org\/10.1128\/mspheredirect.00238-18","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,27]]},"assertion":[{"value":"2018-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00238-18"}}