{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:12:08Z","timestamp":1790471528571,"version":"4.1.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["C26A15PC5N"],"award-info":[{"award-number":["C26A15PC5N"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:p>\n            To our knowledge, this is the first study that investigated the association of\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            with the cervical levels of lactoferrin and selected inflammatory mediators and their correlation with the different community state types characterizing the female genital ecosystem.\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            , known as the leading cause of bacterial sexually transmitted diseases, continues to be an important public health problem worldwide for its increasing incidence and the risk of developing severe reproductive sequelae, like pelvic inflammatory disease and infertility. Specifically,\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            tend to persist in the female genital tract, leading to a chronic inflammatory state characterized by increased production of immune mediators responsible for tissue damage. Therefore, our study may help to broaden the knowledge on the complex interplay between the female genital microbiota and the host immune system in response to\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            infection.\n          <\/jats:p>","DOI":"10.1128\/msystems.00094-19","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T12:55:16Z","timestamp":1559566516000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Selected Immunological Mediators and Cervical Microbial Signatures in Women with Chlamydia trachomatis Infection"],"prefix":"10.1128","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-8588","authenticated-orcid":false,"given":"Simone","family":"Filardo","sequence":"first","affiliation":[{"name":"Section of Microbiology, Department of Public Health and Infectious Diseases, University of Rome \u201cSapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Public Health and Infectious Diseases, University of Rome \u201cSapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Tranquilli","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Public Health and Infectious Diseases, University of Rome \u201cSapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Agnese","family":"Latino","sequence":"additional","affiliation":[{"name":"Unit of Bacteriology, STIs Diagnostic Centre, Sant\u2019Anna Hospital, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Recine","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics and Urology, University of Rome \u201cSapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Porpora","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics and Urology, University of Rome \u201cSapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sessa","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Public Health and Infectious Diseases, University of Rome \u201cSapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/750479"},{"key":"e_1_3_2_3_2","first-page":"229","article-title":"Bacterial vaginosis: a review on clinical trials with probiotics","volume":"36","author":"Mastromarino P","year":"2013","unstructured":"Mastromarino P, Vitali B, Mosca L. 2013. 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