{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:48:40Z","timestamp":1784137720172,"version":"3.55.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSystems"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:p>\n                    Colistin is currently the last-resort antibiotic for difficult-to-treat bacterial infections. However, colistin resistance genes that can move from bacteria to bacteria have emerged, threatening the safe treatment of many bacterial infections. One of these genes,\n                    <jats:italic>mcr-9.1<\/jats:italic>\n                    , has emerged in South Africa in bacteria that are multidrug resistant, further limiting treatment options for clinicians. In this work, we show that this new gene is disseminating worldwide through\n                    <jats:italic>Enterobacter<\/jats:italic>\n                    and\n                    <jats:italic>Salmonella<\/jats:italic>\n                    species through multiple plasmids. This worrying observation requires urgent action to prevent further escalation of this gene in South Africa and Africa.\n                  <\/jats:p>","DOI":"10.1128\/msystems.00148-20","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T09:19:57Z","timestamp":1589793597000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Emergence of\n                    <i>mcr-9.1<\/i>\n                    in Extended-Spectrum-\u03b2-Lactamase-Producing Clinical\n                    <i>Enterobacteriaceae<\/i>\n                    in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome"],"prefix":"10.1128","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-984X","authenticated-orcid":false,"given":"John","family":"Osei Sekyere","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontuthuko E.","family":"Maningi","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"},{"name":"Department of Microbiology, School of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Westville, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesedi","family":"Modipane","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontombi Marylucy","family":"Mbelle","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"},{"name":"National Health Laboratory Services, Tshwane Academic Division, Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. 2017. 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